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Hidden kidney risk during nose surgery? new study investigates

NCT ID NCT07328620

Knowledge-focused Sponsor: Gazi University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looked at whether intentionally lowering blood pressure during nose surgeries (like rhinoplasty) might cause hidden kidney injury. Researchers measured two sensitive kidney biomarkers (NGAL and cystatin C) in 35 adults before and after surgery. The goal was to detect early, silent kidney stress that standard tests might miss.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If this study finds that permissive hypotension causes hidden kidney stress, it could lead to safer blood pressure management during surgeries.
What could go wrong
This is a small, observational study with only 35 participants. It measures temporary biomarker changes, not long-term kidney damage, so results may not change practice.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

35 people

The number who actually took part.

Started

Mar 2025

Finished

Jul 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Adult patients aged 18-65 years undergoing elective rhinologic surgery under controlled hypotension anesthesia at a single tertiary care center will be enrolled. The study population consists of otherwise healthy individuals (ASA I-II) without known kidney disease and without major comorbidities that could independently affect renal function.

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adults aged 18-65 years * Scheduled for elective rhinologic surgery (rhinoplasty, septoplasty, or functional endoscopic sinus surgery) * ASA physical status I-II * Able to provide written informed consent * Undergoing controlled hypotension anesthesia as part of routine clinical management Exclusion Criteria: * Known chronic kidney disease (baseline creatinine above normal range or documented CKD) * Uncontrolled hypertension or uncontrolled diabetes mellitus * Contraindications to controlled hypotensive anesthesia * Pregnant or breastfeeding women * History of major cardiovascular disease affecting renal perfusion (e.g., severe heart failure) * Use of nephrotoxic medications preoperatively that may interfere with renal biomarker interpretation * Perioperative complications requiring deviation from routine anesthetic management (e.g., major bleeding or hemodynamic instability)

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Conditions

The condition(s) this trial relates to.

acute kidney injury hypotensive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Acute kidney injury Hypotension

Contacts and locations

Locations

  • Gazi University Faculty of Medicine

    Ankara, Yenimahalle, 06500, Turkey (Türkiye)

More trials for these conditions

Other studies related to the condition(s) this trial covers.