Could a simple fluid test predict dental implant failure in women after menopause?
NCT ID NCT07785817
First seen Aug 25, 2026 · Last updated Aug 26, 2026 · Updated 1 time
Summary
This study looks at whether certain proteins in the fluid around dental implants can signal early signs of implant disease in postmenopausal women. Researchers will measure levels of aMMP-8 and IL-1β in the crevicular fluid and compare them with clinical and X-ray findings. The goal is to see if these biomarkers can help identify women at higher risk for peri-implantitis, a condition that can lead to bone loss and implant failure.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Biomarker assessment of aMMP-8 and IL-1β in peri-implant crevicular fluid
- What this could lead to
- If successful, this could lead to earlier detection and better risk assessment for peri-implant diseases in postmenopausal women, potentially guiding personalized prevention and treatment.
- What could go wrong
- This is an observational study, so it cannot prove cause and effect. The findings may not apply to all populations, and the proposed biomarker thresholds need further validation.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Participants
-
About 120 people
The number the study aims to enrol. It can still change while the study runs.
- Started
-
Mar 2026
- Expected to finish
-
Feb 2027
An estimate. End dates often move.
- Lead sponsor
-
Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
Postmenopausal women aged 45-70 years with at least one functional dental implant will be recruited from patients attending the Periodontology Clinic. Participants will be classified according to their peri-implant clinical and radiographic status as peri-implant health, peri-implant mucositis, or peri-implantitis.
- Ages
-
45 years and older
- Sex
-
Female participants only
- Healthy volunteers
-
Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Postmenopausal status, defined as amenorrhea for at least 12 months * Aged 45-70 years * Presence of at least one functional dental implant * Completed and functional implant-supported prosthetic restoration * Implant in function for at least 1 year after prosthetic loading * No systemic or local condition preventing clinical or radiographic assessment * Provision of written informed consent Exclusion Criteria: * Current smoking * Presence of uncontrolled systemic disease * Use of antibiotics or anti-inflammatory medications within the past 3 months * Periodontal or peri-implant surgical treatment within the past 6 months * History of radiotherapy to the head and neck region or chemotherapy * Any condition preventing reliable clinical, radiographic, or biochemical assessment
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for Postmenopausal peri-implant health are added.
Genom att skicka in godkänner du våra Användarvillkor
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Istanbul Medipol University
Istanbul, 34200, Turkey (Türkiye)