New combo therapy aims to reverse liver damage in hepatitis b patients
NCT ID NCT07183293
First seen Jun 26, 2026 · Last updated Jun 26, 2026
Summary
This study tests whether adding peginterferon alfa-2b to standard antiviral drugs can improve liver health in people with compensated cirrhosis caused by hepatitis B. Thirty adults will be randomly assigned to receive either the combination or antivirals alone for 48 weeks. Researchers will measure changes in liver scarring, stiffness, and the risk of liver cancer or liver failure.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- peginterferon alfa-2b combined with nucleoside analogues (antiviral drugs)
- What this could lead to
- If successful, this combination could offer a better way to slow or reverse liver damage and lower the risk of liver cancer in people with hepatitis B-related cirrhosis.
- What could go wrong
- This is a small, early-phase study with only 30 participants, so results may not apply broadly. Peginterferon can cause flu-like symptoms and other side effects, and the added benefit over standard antivirals alone is not yet proven.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 30 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Oct 2025
An estimate. Start dates often move.
- Expected to finish
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Sep 2031
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 60 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. Clinical diagnosis of compensated HBV-related liver cirrhosis (Child-Pugh class A or B); 2. The subject is able to understand and comply with the content, requirements, and restrictions of the protocol, is willing and able to complete the study per protocol requirements, fully understands the potential adverse reactions, and voluntarily provides written informed consent prior to study initiation; 3. Aged 18 to 60 years (inclusive), any gender; 4. Female subjects of childbearing potential must have a negative pregnancy test at screening; 5. Subjects (including their partners) must voluntarily use effective non-drug contraception from prior to dosing until six months after discontinuation of the study drug and have no plan to donate sperm or ova; or subjects (including their partners) are of non-childbearing potential (surgically sterilized or postmenopausal). Exclusion Criteria: 1. Decompensated liver cirrhosis, hepatic failure, or hepatocellular carcinoma; presence of other liver diseases such as fatty liver disease, alcoholic liver disease, drug-induced liver injury, autoimmune liver disease, or Wilson's disease; 2. History of clinically significant diseases of the cardiovascular, hematological and lymphatic, respiratory, urinary, endocrine, immune, psychiatric, or nervous systems (e.g., epilepsy), ophthalmic diseases, or thyroid-related disorders; 3. Pregnancy, lactation, or intention to become pregnant during the study period; 4. Known or suspected allergy to the investigational product(s) or any of its excipients; 5. Participation in any other interventional clinical trial within 3 months prior to screening or planning to participate in another clinical trial during the study; 6. Any other condition considered by the investigator to be inappropriate for participation in the study.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
2 sites. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Xiamen Hospital of Traditional Chinese Medicine
Xiamen, China
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Zhongshan Hospital Affiliated to Xiamen University
Xiamen, China
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