New hope for PCOS: supplement combo aims to restore ovulation
NCT ID NCT07630779
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study is for non-diabetic women aged 21-40 with polycystic ovary syndrome (PCOS). It tests whether taking alpha lipoic acid and myo-inositol, either alone or with metformin, can improve menstrual regularity and ovulation. The goal is to manage PCOS symptoms and support fertility, but ongoing treatment is needed.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Phase 3
Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.
- Participants
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About 180 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Mar 2026
- Expected to finish
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Dec 2026
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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21 to 40 years
- Sex
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Female participants only
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Women aged 21 to 40 years * Diagnosed with polycystic ovary syndrome (PCOS) according to Rotterdam criteria * Not currently pregnant or lactating * No hormonal therapy within the last 3 months * Willing and able to provide informed consent Exclusion Criteria: * \- History of diabetes mellitus, hypertension, or thyroid disorders * History of cardiovascular, renal, or hepatic disease * Use of hormonal contraceptives or insulin sensitizers within the last 3 months * Known hypersensitivity or allergy to study medications (myo-inositol, alpha-lipoic acid, or metformin) * Non-Egyptian ethnicity
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Faculty of Medicine, Cairo University
RECRUITINGCairo, Cairo Governorate, Egypt
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Could a diabetes drug ease PCOS? trial tests Mazdutide's effect on hormones
- Antioxidant supplement tested as fertility booster for PCOS
- Fat tissue talks to the ovaries: scientists probe the hidden link
- Acne may signal hidden hormonal disorder in young women
- Can a supplement duo quiet PCOS-Linked inflammation?
- Diabetes drug dapagliflozin takes on metformin in PCOS hormone battle