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Can PCOS change the brain? scientists look inside for answers

NCT ID NCT07727512

Knowledge-focused Sponsor: University of Wisconsin, Madison Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 27, 2026 · Last updated Aug 21, 2026 · Updated 3 times

Summary

This study uses MRI scans to compare brain structure, blood flow, and thinking skills in women with and without polycystic ovary syndrome (PCOS). Researchers want to understand whether PCOS affects overall brain health in reproductive-aged women. Participants complete two visits including brain imaging and cognitive tests over a few months.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If this study finds clear differences in brain health between women with and without PCOS, it could point toward new ways to protect brain function in those with the condition.
What could go wrong
This is a small observational study, not a treatment trial. It can show links but cannot prove cause and effect, and results may not apply to everyone with PCOS.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 45 people

The number the study aims to enrol. It can still change while the study runs.

Started

Aug 2026

Expected to finish

Aug 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Reproductive-aged individuals with ovaries, with and without PCOS

Ages

18 to 45 years

Sex

Female participants only

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria (Participants with PCOS): * Rotterdam criteria demonstrating two out of the three criteria. These are: 1. Presence of clinical hyperandrogenism or biochemical hyperandrogenism 2. A history of irregular menstrual cycles 3. Presence of polycystic ovarian morphology on ultrasound Inclusion Criteria (Healthy Controls): * Regular menstrual cycles (not meeting criteria for irregular cycles above) * No diagnosis of PCOS * Controls may have isolated hirsutism or polycystic ovaries on ultrasound as long as they do not meet Rotterdam criteria for PCOS Exclusion Criteria: * Current pregnancy * Preexisting diagnosis of type 1 diabetes * Severe obesity (body mass index (BMI) greater than 45kg/m2) * Preexisting diagnosis of hypertension requiring antihypertensive medication or blood pressure of greater than 160/100 on two separate occasions during clinical care * History of neurologic disease or stroke * History of myocardial infarction or deep venous thrombosis * Endometriosis confirmed by prior laparoscopy * Autoimmune conditions including lupus, multiple sclerosis, and active malignancy * Immuno-modulating medications * Conditions incompatible with MRI scanning, including but not limited to * Certain implanted metal devices or foreign bodies * Severe claustrophobia * Post-menopausal * Participants will be excluded if they have taken hormonal contraception or fertility medication in the last month

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Conditions

The condition(s) this trial relates to.

polycystic ovary syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PCOS

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • University of Wisconsin

    RECRUITING

    Madison, Wisconsin, 53792, United States

More trials for these conditions

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