New study tests Tooth-Saving fillings to avoid root canals
NCT ID NCT06802549
First seen Jun 26, 2026 · Last updated Jun 26, 2026
Summary
This completed trial tested two dental filling materials, Biodentine and Theracal PT, in 61 adults with deep tooth decay. The goal was to see if these materials could save the tooth and prevent the need for root canal treatment. Participants received a single treatment, and their teeth were checked at 3, 6, and 12 months for healing and pain.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Biodentine and Theracal PT (calcium silicate-based dental cements)
- What this could lead to
- If successful, this could show that these materials effectively treat deep decay and reduce the need for root canals, preserving natural teeth.
- What could go wrong
- This is a small, single-center trial with 61 participants. Results may not apply to all patients, and some teeth may still require root canal treatment if pain persists.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Phase 4
Runs after approval, following long-term safety and how well the treatment works in everyday use.
- Participants
-
61 people
The number who actually took part.
- Started
-
Mar 2024
- Finished
-
Jun 2025
- Lead sponsor
-
Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
-
18 to 50 years
- Sex
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Anyone
- Healthy volunteers
-
Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * • Patient age should be between 18-50 years * Should be able to give written informed consent * Should have systemic status (ASA 1) * Should have permanent molar or premolar (lower and upper) root development * Should be asymptomatic, deep (D3) or extremely deep (D4) caries * Should give vital response in cold test and electric pulp test * Should have teeth where the pulp is exposed with caries * Should not have pain during palpation and percussion * Should not have periodontal disease * Should have restorable teeth * Should have teeth without pulp necrosis, sinus tract or swelling/abscess * Should have bleeding time less than 10 minutes * Should be able to include a maximum of two teeth in a patient in the study (should be in different quadrants and there should be at least 2 weeks between treatment periods) Exclusion Criteria: * Teeth with incomplete root development * Severely affected teeth that do not respond to pulp sensitivity tests * Teeth with signs and symptoms of irreversible pulpitis * Teeth without signs of bleeding after communicating with the pulp chamber * Teeth with pulp chamber open to the oral environment * Teeth with periodontal pockets greater than 4 mm deep * Teeth with suspected cracks or crown fractures that may be responsible for pulp pathology * Teeth with uncontrolled bleeding * Medically at-risk patients will be excluded from the study.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Firat University
Elâzığ, 23119, Turkey (Türkiye)
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