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Simple paper puzzles may boost memory in early Alzheimer's

NCT ID NCT04949750

Symptom relief Sponsor: University of Medicine and Pharmacy at Ho Chi Minh City Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether doing paper-based cognitive training (like memory and attention exercises) could help 70 Vietnamese patients with early Alzheimer's disease. Participants did the training for 12 weeks, and researchers measured changes in memory, thinking, and daily living skills. The goal was to see if this simple, non-drug approach could ease symptoms and support independence.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
paper-based cognitive training
What this could lead to
If it works, this could offer a simple, low-cost way to help people with early Alzheimer's maintain memory and thinking skills.
What could go wrong
This is a small, completed study with no phase designation, so results may not apply broadly. The training is paper-based, which may be less engaging than digital alternatives.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

70 people

The number who actually took part.

Started

Sep 2022

Finished

Jun 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

60 to 80 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * For patient: * Diagnosis of Probable Alzheimer's Disease per DSM-5 criteria; * In the early stage of AD (MMSE from 20 to 25); * Age from 60 - 80 years old; * Had greater than 5 years of formal education. * For Caregiver: * Members (including, but not limited to partners, children, relatives, lived-in helper of the patient) that are important for care delivery and provide care-related tasks (eg personal care, eating, cooking, cleaning) and everyday decision making to the patients. They are not required to live together or spend a specific amount of time with the patients; * Older than 18 years of age; * Possess adequate Vietnamese language skills and no cognitive impairment to conduct interview and evaluation Exclusion Criteria: * For patient: * Patients with concomitant diseases (heart failure, kidney failure, liver failure or thyroid diseases) that affect cognitive functions; * Diagnosed with significant neurologic disease other than AD (Parkinson's disease, multi-infarct dementia, schizophrenia, history of significant head trauma followed by persistent neurologic defaults, …), major depression within the past 1 year, or taking psychoactive medications (antidepressants with significant anticholinergic side effects, neuroleptics, chronic anxiolytics or sedative hypnotics, etc) within the past 1 month; * Having major visual, auditory, reading, or writing impairments; * Patients and/or caregivers who decline to participate. * For cargiver: * Having subjective complaints of cognitive impairment prevents them from understanding the instruction from the research team; * Having significant visual, auditory, reading, or writing impairments; * Caregivers who decline to participate

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Conditions

The condition(s) this trial relates to.

Alzheimer disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Alzheimer disease

Contacts and locations

Locations

  • University Medical Center

    Ho Chi Minh City, 70000, Vietnam

More trials for these conditions

Other studies related to the condition(s) this trial covers.