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Knee replacement pain study seeks best relief combo

NCT ID NCT04513145

Symptom relief Sponsor: OrthoCarolina Research Institute, Inc. Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early This study
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at whether adding a nerve block (adductor canal block) to a standard pain injection around the knee provides extra pain relief for people having total knee replacement. About 93 adults with osteoarthritis participated. The goal was to find the best way to manage pain right after surgery and during recovery.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2/3

Runs two stages together: whether the treatment works, then large-scale confirmation.

Participants

93 people

The number who actually took part.

Started

Oct 2020

Finished

May 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

30 to 85 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1\. Patients age 30-85undergoing first-time primary unilateral total knee arthroplasty for osteoarthritis and remaining hospitalized for at least one night Exclusion Criteria: 1. Patients undergoing revision total knee arthroplasty 2. Patients undergoing bilateral total knee arthroplasty 3. Workers compensation patients 4. Patients undergoing total knee arthroplasty for post-traumatic arthritis 5. Patients with inflammatory arthritis 6. Patients with any previous surgery on the operative knee which involved an arthrotomy 7. Patients taking opioids prior to total knee arthroplasty 8. Patients with a known history of drug or alcohol abuse 9. Patients undergoing total knee arthroplasty at an ambulatory surgery center, or being discharged home from the hospital on the same day as their procedure (planned) 10. Patients who have had a total knee arthroplasty performed on the contralateral knee

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Conditions

The condition(s) this trial relates to.

osteoarthritis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Osteoarthritis Total knee replacement

Contacts and locations

Locations

  • OrthoCarolina Research Institute, OrthoCarolina, P.A.

    Charlotte, North Carolina, 28209, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.