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Laser study on burn scar pain and itch withdrawn before start

NCT ID NCT04364217

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled This study
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study aimed to understand why fractional CO2 laser treatment reduces pain and itch in hypertrophic burn scars. Researchers planned to take small skin samples before and after laser treatment to look at nerve changes. However, the study was withdrawn before any participants were enrolled, so no findings are available.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Fractional CO2 laser (device)
What this could lead to
If successful, this could explain why laser treatment eases pain and itch in burn scars, potentially guiding better scar therapies.
What could go wrong
The study was withdrawn before enrolling anyone, so no results are available. It was a small, early-stage investigation, not a treatment trial.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Started

Jun 2020

Expected to finish

Jul 2025

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 80 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patient must have a hypertrophic burn scar treated by skin grafts or allowed to heal secondarily * Burn must have occurred within the last 2 years from time of recruitment * Patient must have symptoms of pain and/or itch and/or hypersensitivity in the hypertrophic burn scar area * Patient must already be planning to undergo laser treatment for their burn scar * Patient must be willing to undergo biopsy procedures * Patient must be willing and able to participate in the study with a year of follow-up * Not be pregnant or planning to become pregnant during the treatment phase of the study Exclusion Criteria: * Medical Conditions that preclude laser treatment * Active tanning, including the use of tanning booths, during the course of the study * Inability to complete surveys * Previous laser (PDL, CO2), surgical reconstructive treatment procedures done on the hypertrophic burn scar * Current treatment with other procedures or drugs (experimental or other) in area of interest * Medications that interfere with wound healing (oral steroids, immunosuppressive medications, chemotherapy or other) * Medication for itch (steroids, antihistamines, or other) * Medication for pain (opioids, topical pain treatment, gabapentin, ondasetron, paroxetine or other) * Adverse reactions to topical or local anesthetic agents needed for this study, if no alternative to the said agent exists * The study area should not be part of a contracture or other hypertrophic scar that would be better treated with surgical procedures. * The study scar must not be adjacent to/in continuity with areas of HTBS that are planning to be treated with surgical interventions. * Any other condition or laboratory value that would, in the professional opinion of the investigator, potentially affect the subject's response or the integrity of the data or would pose an unacceptable risk to the subject * Patient suffers from epilepsy or seizure disorder.

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Conditions

The condition(s) this trial relates to.

Cicatrix, Hypertrophic Pain Pruritus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Massachusetts General Hospital

    Boston, Massachusetts, 02114, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.