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Spinal injection vs. back block: which eases Post-Surgery pain better?

NCT ID NCT05257941

Symptom relief Sponsor: Indiana University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early This study
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study compared two pain control methods for people undergoing laparoscopic colorectal surgery. One group received a spinal injection of pain medicine, while the other got a nerve block in the back muscles. The goal was to see which approach reduced the need for additional painkillers. The trial was terminated early, so results are limited.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
bupivacaine, duramorph, decadron
What this could lead to
If successful, this could identify a better way to manage pain after laparoscopic colorectal surgery, potentially reducing the need for opioids.
What could go wrong
This trial was terminated early, so results may be incomplete. It is a small, early-phase study, and findings may not apply to all patients or surgeries.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 1/2

Runs two stages together: safety and dose first, then whether the treatment works.

Participants

116 people

The number who actually took part.

Started

Jan 2022

Finished

Aug 2024

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 80 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients undergoing an elective laparoscopic colorectal procedure at Indiana University Hospital or Methodist Hospital * ASA Class 1, 2, 3 (American Society of Anesthesiologists physical status classification system) * Age 18 to 80 years (male or female) * BMI \< 40kg/m2 * Desires regional anesthesia for postoperative pain control Exclusion Criteria: * Any contraindication for neuraxial analgesia or ESP block procedure * Contraindications for neuraxial analgesia include: Elevated intracranial pressure (except in cases of pseudo-tumor cerebri), infection at the site of injection, lack of consent from the patient, patient refusal, true allergy to any drug used in the spine, and uncorrected hypovolemia. * Contraindications for ESP block procedure include: Infection at the site of injection, patient refusal, true allergy to any of the drugs used in the block, and lack of patient consent. * Any patient undergoing a laparoscopic abdominoperineal resection. * Any physical, mental or medical conditions which, in the opinion of the investigators, may confound quantifying postoperative pain resulting from surgery. * Known true allergy to the study medications (morphine, bupivacaine, decadron, Tylenol, Celebrex) * Takes over 30 mg of oral morphine equivalents daily * Any history of substance abuse in the past 6 months * End stage liver disease, end stage renal disease * Body weight of \< 50 kg

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Surgery

Contacts and locations

Locations

  • IU Health University Hospital

    Indianapolis, Indiana, 46202, United States

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