Ozone offers relief for cancer Patients' mouth pain

NCT ID NCT07199712

Completed Symptom relief Sponsor: University of Pavia Source: ClinicalTrials.gov ↗

First seen Nov 01, 2025 · Last updated Jun 18, 2026 · Updated 32 times

Summary

This study tested whether ozone therapy can help heal painful mouth sores caused by radiation and chemotherapy in head and neck cancer patients. Fifty-eight adults used professional ozone treatments at the dentist plus ozone toothpaste, mouthrinse, and gel at home. The main goal was to see how quickly sores healed and how much pain dropped. Results may offer a simple way to improve quality of life during cancer therapy.

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Contacts and locations

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Locations

Unit of Orthodontics and Pediatric Dentistry - Section of Dentistry - Department of Clinical, Surgical, Diagnostic and Pediatrics - University of Pavia

Pavia, Lombardy, 27100, Italy

Conditions

The condition(s) this trial relates to.

agnosia chemotherapy-induced oral mucositis Head and Neck Neoplasms head and neck squamous cell carcinoma mucositis stomatitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CHEMOTHERAPY INDUCED MUCOSITIS HEAD AND NECK CANCER SQUAMOUS CELL CARCINOMA HEAD AND NECK CANCER SQUAMOUS CELL CARCINOMA ORAL MUCOSITIS ORAL STOMATITIS RADIOTHERAPY INDUCED MUCOSITIS