Could ozone gas help relieve dry mouth in cancer survivors?
NCT ID NCT07571356
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests whether injecting ozone gas into the salivary glands can increase saliva production and improve quality of life in people who developed dry mouth after head and neck radiotherapy. One hundred participants will be randomly assigned to receive either ozone injections or no additional treatment. Researchers will measure saliva flow and use questionnaires to assess changes over 12 weekly sessions.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- ozone gas
- What this could lead to
- If it works, this could offer a new, non-drug way to ease dry mouth and improve quality of life for people who have had head and neck radiation.
- What could go wrong
- This is a small, early-stage trial with no comparison to a placebo. The effect may be modest or not last long, and the injections into salivary glands could cause discomfort or side effects.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 100 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Jul 2026
An estimate. Start dates often move.
- Expected to finish
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Jan 2028
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Patients who have undergone head and neck radiotherapy * Patient who have developed xerostomia * Patient who have developed hyposalivation Exclusion Criteria: * Patients with active malignant disease * Patients who do not agree to sign the informed consent form
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
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