Oxygen overload? study links early FiO₂ to sepsis stress marker

This study observes 110 adult ICU patients with sepsis to see if the amount of oxygen given in the first 24 hours is linked to changes in a blood marker called uric acid/albumin ratio (UAR), which reflects oxidative stress and inflammation. Researchers will measure UAR at admission and 24 hours later, and track 28-day survival. The goal is to learn whether too much oxygen may cause extra stress in septic patients, and if UAR can be a simple marker for that damage. No new treatments are tested—only data is collected.