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Osteopathic touch shows promise for depression relief

NCT ID NCT05065580

Symptom relief Sponsor: Corewell Health South Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This completed study tested whether osteopathic manipulative treatment (OMT) – a gentle, hands-on therapy – could help adults with major depressive disorder when added to their usual care. Twenty-five participants received weekly 30-minute OMT sessions for 8 weeks. Researchers measured changes in depression and physical symptom scores before and after treatment. The goal was to see if OMT could be a helpful extra option for managing depression.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
osteopathic manipulative treatment (gentle hands-on techniques)
What this could lead to
If it works, this could point toward a drug-free, hands-on therapy to help ease depression symptoms when used alongside standard care.
What could go wrong
This is a very small, early study with only 25 participants and no control group, so results may not be reliable or apply to everyone. The treatment is only an add-on, not a replacement for proven depression therapies.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

25 people

The number who actually took part.

Started

Mar 2021

Finished

Mar 2023

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * patients 18-65, patients with diagnosis of MDD, PHQ-9 score \> 10 at screening and baseline Exclusion Criteria: * history of mania, hypomania, or psychosis as defined in DSM V * current substance abuse, including abuse within the previous 6 months * patients with a cognitive disorder or dementia * patients with other axis I diagnosis (anxiety disorders, dissociative disorders, etc.) that was primary in the past 6 months * receiving other forms of manual therapy during study * authors belief that there was significant suicidal risk * changes in medication or psychotherapy within 6 weeks of starting study or during study period * history of migraines * presence of any other significant organic disease (infectious, cardiac, pulmonary, gastrointestinal, renal, etc.) * other absolute contraindications to OMT (malignancy, infection, myelopathy, severe osteoporosis, increased ICP, intracranial bleeding, fractures, etc.)

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Conditions

The condition(s) this trial relates to.

major depressive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Major depressive disorder

Contacts and locations

Locations

  • Lakeland Regional Healthcare

    Saint Joseph, Michigan, 49085, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.