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Simple blood test could spot osteoarthritis years earlier

NCT ID NCT07544823

Diagnosis Sponsor: The First Affiliated Hospital of Xinxiang Medical College Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study aims to find blood-based biomarkers that can diagnose osteoarthritis (OA) earlier than current methods. Researchers will collect blood samples from 300 people aged 40-70 with joint pain to test previously identified candidate markers. The goal is to develop a simple, reliable blood test for early OA detection, potentially enabling earlier treatment and reducing long-term disability.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this could lead to a simple blood test for early osteoarthritis detection, allowing for earlier intervention and better management.
What could go wrong
This is an observational study, not a treatment trial. The biomarkers identified may not prove reliable in larger, more diverse populations.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 300 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Apr 2026

An estimate. Start dates often move.

Expected to finish

Dec 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

The study subjects shall include patients with osteoarthritis (OA) at different anatomical sites as far as possible, such as the knee, hip and hand. Enrollment will focus on early-stage OA patients with Kellgren-Lawrence (K-L) grade 1-2. Meanwhile, patients with diseases that share similar clinical manifestations with OA and are prone to misdiagnosis shall also be enrolled.

Ages

40 to 70 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Aged between 40 and 70 years (inclusive); 2. Joint pain or stiffness lasting for no less than 3 months; 3. Voluntary participation with signed informed consent. Exclusion Criteria: 1. Combined with other severe joint diseases, such as rheumatoid arthritis, gout, etc.; 2. Suffering from severe systemic diseases, such as heart failure, malignant tumors and others; 3. Received joint surgery within the past 3 months or taking medications that may affect the progression of osteoarthritis; 4. Individuals with cognitive dysfunction who are unable to cooperate with the research procedures; 5. Failure to complete X-ray, MRI examination or follow-up visits as required.

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Conditions

The condition(s) this trial relates to.

osteoarthritis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Osteoarthritis (OA)

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • The First Affiliated Hospital of Henan Medical University

    RECRUITING

    Xinxiang, Henan, 453003, China

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