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Could a simple change in braces procedure lead to better tooth alignment?

NCT ID NCT07733258

Disease control Sponsor: Dow University of Health Sciences Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 29, 2026 · Last updated Jul 30, 2026 · Updated 1 time

Summary

This clinical trial investigates whether separating the aligning and leveling phases of orthodontic treatment can better control the tilt of lower front teeth in adults with crowded teeth. Participants aged 18 to 30 with specific dental conditions will receive fixed braces using heat-activated nickel-titanium archwires. The study will measure changes in tooth inclination and the flattening of the curve of Spee over six months to see if this phased approach improves outcomes.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
separating the aligning and leveling phases of orthodontic treatment using heat-activated nickel-titanium archwires
What this could lead to
If it works, this could lead to a more effective orthodontic technique for controlling lower front tooth position during braces treatment.
What could go wrong
This is a small, early-stage trial with only 36 participants, so results may not apply to everyone. The intervention is a procedural change, not a new drug, so the potential impact is modest.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

36 people

The number who actually took part.

Started

Oct 2023

Finished

Oct 2024

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 30 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients aged 18-30 years age * Skeletal Class 1 * Angle class 1 malocclusion * Little's irregularity index falls between 4-8mm * Curve of spee depth 3-4mm * Non-extraction Orthodontic plan Exclusion Criteria: * Previous Orthodontic treatment * Advanced periodontal problem * Drug used that modify bone metabolism * Growing patients * Patient with anterior mandibular spacing * Systemic Disease (uncontrolled diabetes Mellitus etc )

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Alignment Leveling and alignment of teeth

Contacts and locations

Locations

  • Dr Ishrat ul Ebad Khan Institute of Oral Health Sciences

    Karachi, Sindh, 75300, Pakistan