Lab-Grown tumor clones could personalize sarcoma treatment

This study tests a new approach for people with advanced leiomyosarcoma, a rare cancer of smooth muscle. Researchers grow a mini version of each patient's tumor in the lab (called an organoid) and test which drugs work best. Then, patients receive a personalized first-line treatment based on those results. The goal is to see if this method improves tumor shrinkage and delays cancer growth. The study enrolls 50 adults who have not yet had systemic treatment for advanced disease.