Liver cancer drug combo shows different results in different organs
NCT ID NCT04862949
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study looked at how a combination of two drugs (atezolizumab and bevacizumab) works on liver cancer tumors in different parts of the body. Researchers wanted to see if the drugs work better on tumors in some organs than others. The study included 131 people with advanced liver cancer who had not received prior treatment. The goal was to understand which tumors respond best to this therapy.
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Study facts
What this study's own registry entry says, in plain language.
- Participants
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131 people
The number who actually took part.
- Started
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May 2021
- Finished
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Mar 2023
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
Patients enrollment was performed in the CHA Bundang Medical Center, Ulsan University Hospital and Chinese University of Hong Kong
- Ages
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19 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Confirmed HCC pathological or non-invasive assessment according to American Association for the Study of Liver Diseases (AASLD) criteria * ECOG performance status 0 or 1 * Patients who received Atezolizumab and Bevacizumab combination therapy as first-line systemic treatment for unresectable HCC * Barcelona Clinic Liver Cancer (BCLC) stage B or C * Child-Pugh class A * Measurable lesion * Adequate hematologic and organ function Exclusion Criteria: * History of autoimmune disease * Concomitant anticoagulation at therapeutic doses. Low dose aspirin for * cardio protection is permitted.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Cha Medical Center
Seongnam-si, Gyeonggi-do, 13496, South Korea
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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- Promising drug cocktail targets Hard-to-Treat liver cancer