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Breathing exercises may retrain swallowing in ICU survivors — a trial puts it to the test

NCT ID NCT07736105

Disease control Sponsor: Vanderbilt University Medical Center Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 30, 2026 · Last updated Sep 10, 2026 · Updated 3 times

Summary

This study compares three approaches to treating swallowing problems in adults recovering from critical illness: standard care, intensive swallowing exercises, and a device that strengthens breathing muscles. Researchers will measure changes in swallowing safety, cough strength, and frailty, and also ask patients and speech therapists about how practical the treatments are. The goal is to find a feasible, effective therapy for a condition that currently has few proven options.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
expiratory muscle strength training (EMST) and intensive dysphagia treatment
What this could lead to
If effective, these exercises could provide a practical, targeted treatment for swallowing problems in critically ill patients, potentially reducing complications like pneumonia.
What could go wrong
This is a relatively small, early-stage trial, and the exercises may be too demanding for some very ill patients. Results may not apply to all hospital settings.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 120 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Apr 2027

An estimate. Start dates often move.

Expected to finish

Feb 2029

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion criteria for critically ill adults will be: 1. Adult ≥ 18 years old 2. Not pregnant 3. Underwent a clinical flexible endoscopic evaluation of swallowing (FEES) or videofluoroscopy swallow study (VFSS) with a penetration aspiration scale (PAS) score ≥ 5 4. Hospitalized in non-neuro intensive care unit (ICU) setting at Vanderbilt University Medical Center (VUMC) at some point during admission 5. Dysphagia is primarily related to ICU stay and not other medical conditions that may cause dysphagia 6. medically cleared with no contraindications for expiratory muscle strength training (EMST) or other treatments 7. Cognitive capacity to follow basic directions 8. Willing to undergo testing and treatment for the study. Inclusion criteria for speech-language pathologists (SLPs) will be: 1. Adult acute care speech-language pathologist who works at VUMC. 2. Willing to complete surveys and/or participate in a focus group.

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Conditions

The condition(s) this trial relates to.

Cough Critical Illness Deglutition Disorders Respiratory Aspiration

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Critical illness Dysphagia

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Vanderbilt University Medical Center

    Nashville, Tennessee, 37232, United States

More trials for these conditions

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