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Timing the first epidural bolus: a key to better labor pain relief?

NCT ID NCT03044392

Symptom relief Sponsor: IWK Health Centre Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early This study
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looked at the best time to give the first dose of pain medicine through an epidural pump during labor. 84 women in labor were assigned to receive the first dose at 15, 30, or 45 minutes after starting the pump. The goal was to find a timing that provides good pain relief while using less medicine and reducing side effects like itching or low blood pressure. The trial was stopped early, so the results are not final.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
local anesthetic and opioid (via epidural pump)
What this could lead to
If successful, this could help hospitals set the best timing for the first epidural dose, improving pain relief and reducing side effects for women in labor.
What could go wrong
The trial was terminated early with only 84 participants, so results are limited. The optimal interval may vary for different patients or hospitals.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

84 people

The number who actually took part.

Started

Jun 2017

Finished

Nov 2018

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 45 years

Sex

Female participants only

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * • American Society of Anesthesiologists (ASA) Physical Status I-II (ASA I - Healthy, ASA II - mild and controlled systemic disease) * Spontaneous labour * Nulliparous parturient * Single gestations ≥ 36 weeks * English speaking * Age 18-45 years * Vertex presentation * Requesting an epidural for labour analgesia * Cervical dilation less than 2 cm or greater than 6 cm at the time of initiation of neuraxial analgesia Exclusion Criteria: * • Use of IV opioids within 1 hour of initiating the epidural * Use of nitrous oxide after initiating the epidural pump * Contraindications to neuraxial analgesia (i.e. coagulopathy, infection, neuropathy) * Abnormal spinal anatomy (i.e. scoliosis, spina bifida, spinal instrumentation) * Height \< 5'0" or BMI ≥ 40 kg/m2 * Chronic analgesics * Diseases of pregnancy (i.e. hypertension, preeclampsia, gestational diabetes) * Severe maternal cardiac disease * Known fetal anomalies /intrauterine fetal demise * Physical or psychiatric condition which may impair cooperation

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Conditions

The condition(s) this trial relates to.

Labor Pain Pain

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Labor pain

Contacts and locations

Locations

  • IWK Health Centre

    Halifax, Nova Scotia, B3K 6R8, Canada

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