New creatine formula tested for better absorption and less stomach trouble
NCT ID NCT07225335
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tested a new creatine supplement called OptiCreatine against standard creatine monohydrate in 17 healthy, active adults. The goal was to see if OptiCreatine leads to higher creatine levels in the blood and fewer stomach issues. Participants took both supplements at different times, and researchers measured absorption and digestive comfort.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- OptiCreatine (a dietary supplement combining creatine with other compounds)
- What this could lead to
- If OptiCreatine works better, it could mean less stomach discomfort and better absorption for people who take creatine supplements.
- What could go wrong
- This was a very small study (17 people) in healthy adults, so results may not apply to everyone. The supplement industry often makes bold claims that don't hold up in larger trials.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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17 people
The number who actually took part.
- Started
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Nov 2025
- Finished
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Dec 2025
- Lead sponsor
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A company
The lead sponsor is a pharmaceutical, biotech, or medical-device company.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 45 years
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Adults between the ages of 18-45 yrs * Body mass index of \<35 kg/m2 * Recreationally active \[≥30 minutes of moderate-intensity physical activity per week as defined by the International Physical Activity Questionnaire (IPAQ)\] * Participant is healthy and free from disease as determined by a health history questionnaire. * Participant agrees to abstain from caffeine (24 hrs. prior), tobacco (24 hrs. prior), and alcohol (24 hrs. prior) before testing days Exclusion Criteria: * Has chronic kidney disease, liver disease, chronic obstructive pulmonary disease, or cancer * Currently using medications that may directly impact the primary outcomes including: diuretics and corticosteroids) * Currently using creatine monohydrate * Has severely impaired hearing or speech or inability to speak English
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Applied Physiology Laboratory (Fetzer Hall, Room 025)
Chapel Hill, North Carolina, 27599-8700, United States
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