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Pain relief without opioids: safer anesthesia option found

NCT ID NCT07310524

Symptom relief Sponsor: Muhammad Rahman Efendi Nasution Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether avoiding opioids during anesthesia could still control pain during abdominal surgery. 42 adults were randomly assigned to receive either opioid-free anesthesia (using ketamine, lidocaine, and dexmedetomidine) or standard opioid-based anesthesia (using fentanyl). Both methods worked equally well for pain control, but the opioid-free group had significantly less nausea and vomiting after surgery. This suggests opioid-free anesthesia is a safe and effective alternative that reduces common side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

42 people

The number who actually took part.

Started

Sep 2025

Finished

Dec 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: Adult patients aged 18-65 years Patients undergoing elective abdominal surgery (e.g., laparotomy, colectomy, cystectomy, etc.) American Society of Anesthesiologists (ASA) physical status I-II Undergoing general anesthesia with endotracheal intubation Undergoing abdominal surgery with a duration of less than 4 hours Willing to participate in the study and sign the informed consent form Patients who are extubated in the operating room after completion of the surgical procedure Exclusion Criteria: Patients with neurological disorders (e.g., epilepsy, stroke, altered level of consciousness) History of severe psychiatric disorders or long-term use of psychotropic medications Patients with a history of cardiac arrhythmias and/or prior use of antiarrhythmic drugs and/or those with a pacemaker Patients with increased intracranial pressure Patients on chronic opioid therapy or other chronic pain treatments Patients with severe hemodynamic instability (hypotension/shock, unstable arrhythmias) Patients with a history of allergy to medications used in this study

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Opioid-free anesthesia

Contacts and locations

Locations

  • RSUP H. Adam Malik Medan

    Medan, North Sumatra, 20146, Indonesia

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