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Custom breathing support during lung surgery may cut risks

NCT ID NCT07387822

Disease control Sponsor: Aerospace Center Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether tailoring breathing machine settings to each patient during lung surgery can lower the chance of lung problems like pneumonia or breathing failure. About 352 adults having video-assisted lung surgery will be randomly assigned to either standard ventilation or a personalized approach that adjusts air pressure to keep lungs open. The main goal is to see if personalized ventilation reduces complications within the first week after surgery.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Individualized Open Lung Ventilation (procedure)
What this could lead to
If it works, this could point toward a safer way to ventilate patients during lung surgery, reducing serious breathing complications.
What could go wrong
This is a single-center trial with 352 participants, so results may not apply to all patients. The personalized approach may not lower complication rates compared to standard care.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 352 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Feb 2026

An estimate. Start dates often move.

Expected to finish

May 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 75 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age 18 to 75 years. * American Society of Anesthesiologists (ASA) physical status I-III. * Body mass index between 18 and 30 kg/m². * Scheduled for elective video-assisted thoracoscopic surgery (VATS). * Expected duration of one-lung ventilation longer than 1 hour. * Able to understand the study procedures and provide written informed consent. Exclusion Criteria: * Pregnancy or breastfeeding. * Emergency surgery or reoperation. * History of severe pulmonary disease, including chronic obstructive pulmonary disease, pulmonary fibrosis, severe emphysema, pulmonary bullae, pneumothorax, or uncontrolled asthma. * History of heart failure or coronary artery disease. * Previous thoracic surgery or mechanical ventilation within 1 month before surgery. * Planned postoperative mechanical ventilation. * Bilateral thoracic surgery. * Participation in another interventional clinical trial. * Conversion to open thoracotomy during surgery.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

One-lung ventilation (OLV) Postoperative pulmonary complications (PPCS) Thoracic surgery, video assisted

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Aerospace Center Hospital

    Beijing, China

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