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Common nausea drug beats ketamine in stopping Post-Surgery shivers

NCT ID NCT07334223

Symptom relief Sponsor: Mayo Hospital Lahore Source: ClinicalTrials.gov ↗

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

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Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Sep 17, 2026 · Updated 2 times

Summary

This study tested whether ondansetron (a nausea drug) or low-dose ketamine (a painkiller) works better to prevent shivering after spinal anesthesia. 180 adults having elective surgery took part. Results showed ondansetron caused shivering in 30% of patients, while ketamine caused it in 44%, making ondansetron the more effective option.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

180 people

The number who actually took part.

Started

Jul 2020

Finished

Jan 2021

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

20 to 70 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients of either gender aged 20-60 years with ideal body * weight of 50 to 80 kg. * Patients meeting ASA classification I and II determined by * anesthesiologist. * Patients undergoing elective surgeries under spinal anesthesia. * Duration of surgery should not be more than 3 hours. Exclusion Criteria: * Patients having a documented history of severe adverse reactions to ketamine or ondansetron. * Patients with cardiovascular disease documented in history. * Patients with hepatic disease documented in history and supported by lab results (AST 32-40U/L), ALT(10-40U/L). * Patients with renal disease documented in history and supported by lab results. Urea (10-50mg/dl) S/Creatinine (0.3-1.5mg/dl). * Patients with hyperthyroidism documented in history and supported by lab results. * Patients with history of mental illness, seizures and glaucoma. * Patients with known hypertension (BP greater than 140/90). * Haemodynamically unstable patients (BP\<100mmHg). * Patients with coagulopathy or other bleeding diathesis documented in history and supported by lab results. * Complicated prolonged surgeries in spinal anesthesia.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Postoperative shivering Postspinal shivering

Contacts and locations

Locations

  • Mayo Hospital, Lahore

    Lahore, Punjab Province, 54000, Pakistan

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