New wash may ease pain and nausea after gallbladder surgery

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Eligible participants will be adult patients scheduled for elective laparoscopic cholecystectomy at the study site. To ensure a homogeneous sample appropriate for this pilot trial, strict inclusion and exclusion criteria have been defined. Inclusion criteria Patients meeting all the following criteria will be considered for enrollment: 1. Aged between 18 and 60 years. 2. American Society of Anesthesiologist (ASA) physical status classification I or II. 3. Scheduled for elective laparoscopic cholecystectomy due to symptomatic cholelithiasis, resolved choledocholithiasis post-endoscopic retrograde cholangiopancreatography (ERCP), or gallbladder polyp. 4. Placement of a ¾-inch Penrose drain in the subhepatic cavity as part of the standardized surgical technique, to allow evacuation of residual CO2, residual lavage fluid, and close monitoring for possible postoperative bleeding or bile leakage. 5. Intraoperative surgical difficulty assessed as Grade I, II or III according to the Nassar scale 6. Ability to provide written, informed consent Exclusion Criteria Patients presenting with any of the following will be excluded: 1. Confirmed pregnancy or lactation 2. Intraoperative findings of Nassar Grade IV, suspected gallbladder cancer, scleroatrophic gallbladder, or cirrhosis 5\. Use of NSAIDs within 24 hours prior to surgery, or chronic use of NSAIDs, opioids, immunosuppressants, chemotherapy, or anticoagulants. 6\. Known allergies to ondansetron, acetaminophen, diclofenac sodium, buprenorphine or tramadol 7\. Significant cardiac disease (e.g., heart failure, arrhythmias, pacemaker dependency) 8\. Obesity Grade IV (Body Mass Index ≥ 50 kg/m2) 9\. History of recurrent vertigo or motion sickness Elimination Criteria Patients who meet inclusion criteria but experience the following intraoperative events will be eliminated from the final per-protocol analysis: significant bleeding or bile duct injury requiring re-intervention, conversion to open surgery, or a total operative time exceeding 80 minutes.