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Hands-On therapy and simple exercises may ease stubborn headaches

NCT ID NCT05617365

Symptom relief Sponsor: Michigan State University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study tests whether combining osteopathic manipulation (a hands-on therapy) with targeted head exercises can reduce headache frequency, intensity, and duration in women with chronic cervicogenic headache—a type of headache caused by neck problems. Thirty women aged 18 to 75 will be randomly assigned to receive the treatment or standard medical care over 12 weeks. The goal is to see if the treatment improves symptoms and restores normal neck muscle function.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
osteopathic manipulation and targeted head exercises
What this could lead to
If successful, this could provide a non-drug treatment option to reduce chronic headache pain and improve neck muscle health.
What could go wrong
This is an early-phase study with only 30 participants, so results may not apply to everyone. The treatment may not work better than standard care.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 1/2

Runs two stages together: safety and dose first, then whether the treatment works.

Participants

About 30 people

The number the study aims to enrol. It can still change while the study runs.

Started

Sep 2022

Expected to finish

Jun 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 65 years

Sex

Female participants only

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: Females diagnosed with chronic cervicogenic headache. Exclusion Criteria: * Have you been involved in a rear-end motor vehicle accident within the past 3 years? * Have you had spinal surgery performed on your neck? * Do you have a pinched nerve in the neck that produces pain radiating down your arm. * Have you been diagnosed with diseases such as rheumatoid arthritis, lupus, or ankylosing spondylitis. * Do you have ongoing central nervous system pathology such as hemiparesis, cervical radiculopathy, spondylolisthesis grade III or IV, central nervous system causes of balance \& coordination deficits, orthostatic hypotension, vestibular disorders, pregnancy, recent spinal fractures, moderate to severe traumatic brain injury.

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Conditions

The condition(s) this trial relates to.

Neck Pain Post-Traumatic Headache

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cervicogenic headache Neck pain, posterior

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Michigan State University

    RECRUITING

    East Lansing, Michigan, 48824, United States

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