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Hands-On therapy may rewire headache brains, pilot study shows

NCT ID NCT06841627

Knowledge-focused Sponsor: Edward Via Virginia College of Osteopathic Medicine Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at how osteopathic manual therapy (OMT) changes the brain in people with migraines, tension, or cluster headaches. Researchers used MRI scans to see if OMT affects brain structure and activity. The goal was to understand how OMT reduces pain and disability, not to test a new treatment. 31 adults with frequent headaches took part.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

31 people

The number who actually took part.

Started

Aug 2025

Finished

May 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 60 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * current diagnosis of primary headache (migraine, tension-type, cluster) from a healthcare provider * have experienced at least one headache episode a month for the previous 1 year (or longer) * age of PH onset was less than 50 years, currently taking medication for headaches. Exclusion Criteria: * presence of headaches due to some other underlying medical condition (secondary headaches) * traumatic brain injury * fibromyalgia, epilepsy * diagnosis of a neurodegenerative disorder * history of brain tumor or cancer * history of cervical radiculopathy (pinched nerve in the neck) * currently undergoing manual therapy type treatment or have a a treatment within 2 weeks of enrollment(chiropractic, OMT, massage, PT) * currently pregnant * have had an injection to treat headaches within the previous 3 months from study enrollment * contraindications to MRI.

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Conditions

The condition(s) this trial relates to.

cluster headache syndrome Headache headache disorder migraine disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Primary headaches (migraines, tension, cluster headaches)

Contacts and locations

Locations

  • Auburn University MRI Center and Edward Via College of Medicine

    Auburn, Alabama, 36832, United States