Natural supplement shows promise for borderline high cholesterol

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

The study will include subjects of both sexes: * aged between 18 and 70; * able to understand and sign the informed consent; * Negative HIV test * Negative pregnancy test * Borderline total cholesterol values, between 200 and 239 mg/dL (National Institute of Health definition) * LDL cholesterol values \< 159 mg/dL (https://www.humanitas-care.it/malattie/colesterolo/)\* * Who are not taking any medications and will not take any medication throughout the study period \* Mildly altered LDL cholesterol between 100 and 159 mg/dL (NCEP Guidelines): * Optimal: less than 100 mg/dL * Near optimal/above optimal: 100 to 129 mg/dL * High limit: 130 to 159 mg/dL * High: 160 to 189 mg/dL * Very high: greater than 190 mg/dL Education Guidelines National Cholesterol Education Program (NCEP) "Executive summary of the third report of the National Cholesterol Education Program (NCEP) expert panel on the diagnosis, evaluation, and treatment of hypercholesterolemia in adults (Adult Treatment Panel III)" (Revised\_2013) https://www.ncbi.nlm.nih.gov/books/NBK542294/#article-19466.r18 Subjects with the following characteristics will be excluded from the study: * Age \< 18 and \> 70 years; * subjects exposed to a high risk of cardiovascular events based on 8 risk factors (gender, age, diabetes, smoking, systolic blood pressure, total cholesterol, HDL cholesterol, and antihypertensive treatment) in accordance with the parameters of the Istituto Superiore di Sanità's Cuore project (http://www.cuore.iss.it/sopra/calc-rischio.asp), * undergoing pharmacological therapy for cholesterol and/or hyperglycemia, even at low doses, * taking supplements to control cholesterol, blood sugar, and metabolic syndrome in the two weeks prior to recruitment, * pregnant women, women who are pregnant or planning to become pregnant, * breastfeeding women, * blood donors in the three months prior to recruitment, * non-self-sufficient subjects, * subjects who show no willingness to cooperate, * subjects who have difficulty reaching the clinic reference facility within the required timeframe, * subjects deemed unsuitable by the investigating physician due to the presence of other conditions deemed incompatible with enrollment and requiring pharmacological treatments, * subjects with HIV-associated immunodeficiency, * subjects with known allergies to the ingredients of the study product, * subjects who consume alcohol in quantities greater than 30g/day for men and 20g/day for women, * subjects who use drugs of abuse. * subjects taking medications.