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Sugar drink study reveals why some brains crave more food

NCT ID NCT05200845

Knowledge-focused Sponsor: Virginia Polytechnic Institute and State University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 26, 2026 · Updated 1 time

Summary

This study looked at how the body processes nutrients and whether that affects food cravings in people with different body weights. Twenty participants drank flavored beverages with sugar and rated how much they liked them. Researchers also measured blood sugar and metabolism. The goal was to see if people with obesity respond differently to sugar-linked rewards, which could help explain why some find it harder to resist high-calorie foods.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Flavored beverage with 75 calories of sucrose
What this could lead to
If successful, this could help explain why some people crave sugary foods more than others, pointing toward new ways to manage weight.
What could go wrong
This is a very small pilot study with only 20 people, so results may not apply to everyone. It only looks at short-term responses, not long-term weight loss.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

20 people

The number who actually took part.

Started

Feb 2022

Finished

Jun 2023

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 45 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. BMI between 18.5-40 kg/m2 2. Not pregnant or planning to become pregnant during study participation 3. Residing in the Roanoke area and/or willing/able to attend sessions at the Fralin Biomedical Research Institute 4. Able to speak and write in English 5. Specific to fMRI scan only: BMI between 25-35 kg/m2 Exclusion Criteria: 1. Current inhaled nicotine use 2. History of alcohol dependence. 3. Current or past diagnosis of diabetes or thyroid problems. 4. Glycated hemoglobin (Hemoglobin A1C) \>5.7% 5. Taking medications known to influence study measures (including antiglycemic agents, thyroid medications, sleep medications) 6. Active medical or neurologic disorder. 7. Recent change in body weight (gain or loss of \> 5 lbs within the past 3 months) 8. Current shift work (typical pattern of work/activity overnight) 9. Previous weight loss surgery 10. Adherence to a special diet within the past 3 months (e.g., low-carb or ketogenic diet, exclusion of food groups/specific macronutrients, intermittent fasting, etc.) 11. Allergy to any food or ingredient included in the study diets, meals, or beverages 12. Currently pregnant or planning to become pregnant during study participation 13. Claustrophobia 14. Contraindications for MRI, including pacemaker, aneurysm clips, neurostimulators, cochlear or other implants, metal in eyes, regular work with steel, etc. (Note: This is an fMRI-specific exclusion criterion. Participants may be allowed to participate in all other study sessions and measures that do not involve fMRI.) 15. Contraindications for bioelectrical impedance analysis, specifically implanted devices

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Conditions

The condition(s) this trial relates to.

Obesity obesity disorder Overweight

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Overweight and obesity

Contacts and locations

Locations

  • Fralin Biomedical Research Institute at Virginia Tech Carilion

    Roanoke, Virginia, 24016, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.