C-Section blood pressure battle: which drug wins?
NCT ID NCT06498076
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tested two drugs, norepinephrine and ephedrine, to prevent and treat low blood pressure during planned C-sections under spinal anesthesia. 196 healthy pregnant women were randomly assigned to receive one of the two drugs. Researchers tracked how many doses were needed and monitored side effects for both mother and baby. The goal is to find which drug works better and is safer.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- norepinephrine and ephedrine
- What this could lead to
- If it works, this could point toward a safer, more effective way to manage low blood pressure during C-sections, reducing risks for both mother and baby.
- What could go wrong
- This is a small, single-center study with only 196 participants. Results may not apply to all patients or settings, and both drugs have known side effects like rapid heart rate or high blood pressure.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
-
196 people
The number who actually took part.
- Started
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Aug 2024
- Finished
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Jan 2025
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
-
18 to 38 years
- Sex
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Female participants only
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Singleton full-term consenting pregnant females of ASA grade II, aged 18-38 years, scheduled for elective cesarean section under spinal anesthesia Exclusion Criteria: * Any parturient falling in the category ASA grade III and IV, contrindications to spinal anesthesia, preeclampsia, chronic hypertension, comorbidity with diabetes mellitus, cardiovascular disorders and psychiatric illness are non included. They are excluded the case of failure of spinal anesthesia, conversion to general anesthesia, post-partum bleeding, and failure to follow protocol.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Charles Nicolle Hospital
Tunis, Tunis Governorate, 1006, Tunisia
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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- A single class may help new mothers avoid Long-Term pain after C-Section
- Could a 20% lower anesthetic dose make C-Sections safer?
- Can a single dose extend Post-Cesarean pain relief?
- Could having a partner present during emergency C-Sections improve Mothers' mental health?
- When pain strikes during C-Section: what Women's stories reveal