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Tiny plaques, big clues: new study links early artery buildup to blood changes

NCT ID NCT03632785

Knowledge-focused Sponsor: University of Sao Paulo Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at 90 people with low or medium heart risk to see if tiny, non-blocking plaques in the heart arteries affect how blood clots and how blood vessels work. Participants had a special CT scan to find these small plaques, and their blood was tested for clotting activity. The goal was to better understand early warning signs of heart problems, not to test a treatment.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

90 people

The number who actually took part.

Started

Mar 2017

Finished

Dec 2019

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Patients older than 18 years, male and female with low and medium risk of cardiovascular disease without atherosclerotic disease manifest.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Low or Medium Risk of cardiovascular disease assessed by the Framingham criteria; * That agrees to sign the Consent Form; * Absence of known atherosclerotic disease; * Patients in the case group should additionally present discrete plaques (s) evaluated by coronary angiotomography of multiple detectors (CAMD). Patients in the control group should be absent from any coronary atherosclerotic process to CAMD. Exclusion Criteria: * Known atherosclerotic disease manifest; * Previous acute coronary syndrome (ACS); * Use of antiplatelet agents and / or anticoagulants; * Use of NSAIDs and/or corticosteroids * Known platelet dysfunction or platelets \<100,000 / μL or\> 450,000 / μL * Hematocrit \<33% and \> 52% * Hematological diseases; * Liver disease; * Known malignant neoplasm; * Refusal to sign free and informed consent.

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Conditions

The condition(s) this trial relates to.

coronary stenosis nonobstructive coronary artery disease platelet aggregation, spontaneous

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cardiovascular risk factor Coronary angiography of multiple detectors Discrete coronary artery stenosis Platelet aggregation, spontaneous

Contacts and locations

Locations

  • José Carlos Nicolau

    São Paulo, São Paulo, 05403-900, Brazil

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