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MRI-Guided chemo reduction trial aims to spare TNBC patients from toxic drugs

NCT ID NCT07327021

Recruiting now Disease control Sponsor: Tel-Aviv Sourasky Medical Center Source: ClinicalTrials.gov ↗

First seen Jan 08, 2026 · Last updated Jun 15, 2026 · Updated 23 times

Summary

This study tests whether MRI scans can identify triple-negative breast cancer patients who respond well to initial chemotherapy and immunotherapy, allowing them to skip the second, more toxic phase of treatment. About 54 participants will receive four cycles of a chemo-immunotherapy combo, then get an MRI. Those with a complete response on MRI will go straight to surgery, avoiding anthracycline drugs linked to heart problems and leukemia. The goal is to maintain high cure rates while reducing side effects.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Sheba Medical Center

    RECRUITING

    Tel Litwinsky, Israel

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • Tel Aviv Sourasky Medical Center

    RECRUITING

    Tel Aviv, Israel

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

Conditions

The condition(s) this trial relates to.

breast neoplasm triple-negative breast carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

EARLY BREAST CANCER EARLY BREAST CANCER EARLY BREAST CANCER TNBC - TRIPLE-NEGATIVE BREAST CANCER