New combo aims to shrink Hard-to-Treat colorectal tumors

NCT ID NCT05308446

Disease control Sponsor: National Cancer Institute (NCI) Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jul 09, 2026 · Updated 3 times

Summary

This phase II trial tests whether adding the immunotherapy drug nivolumab to the standard two-drug regimen (encorafenib and cetuximab) works better at shrinking tumors in people with a specific type of advanced colorectal cancer (BRAF-mutant, microsatellite stable). About 86 participants will be randomly assigned to receive either the two-drug or three-drug combination. The goal is to see if the triple therapy improves how long the cancer is kept under control.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance: encorafenib, cetuximab, and nivolumab
What this could lead to: If it works, this could offer a more effective treatment option for people with a hard-to-treat form of colorectal cancer that has spread.
What could go wrong: This is a mid-stage trial with only 86 participants, so results may not apply to everyone. Adding immunotherapy can also cause immune-related side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

86 people

The number who actually took part.

Started

Jul 2022

Expected to finish

Jun 2027

An estimate. End dates often move.

Lead sponsor

A government research agency

The lead sponsor is the US National Institutes of Health.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Participants must have a histologically or cytologically confirmed diagnosis of adenocarcinoma of the colon or rectum. The date of diagnosis will be determined according to the pathologic date of diagnosis * Participants must have measurable disease according to RECIST1.1 criteria. Computed tomography (CT) scans or magnetic resonance imaging (MRIs) used to assess measurable disease must have been completed within 28 days prior to registration. CT scans or MRIs used to assess non-measurable disease must have been completed within 42 days prior to registration. All disease must be assessed and documented on the Baseline Tumor Assessment Form * Participants must have documented unresectable and/or metastatic disease on CT or MRI imaging. All disease must be assessed and documented on the Baseline Tumor Assessment Form * Participants must have BRAF\^V600E mutated colorectal cancer as tested in a Clinical Laboratory Improvement Act (CLIA)-certified laboratory * Participants must have proficient mismatch repair (pMMR) or microsatellite stable (MSS) status as tested in a CLIA-certified laboratory and documented by the treating clinician. Proficient mismatch repair status can be determined by intact expression by immunohistochemistry of all 4 mismatch repair proteins (MLH1, MSH2, MSH6, and PMS2). Microsatellite instability can be determined by polymerase chain reaction (PCR) * Participants with brain metastases must have completed surgery or radiation therapy \>= 28 days prior to registration. These participants must have a CT or MRI of the brain showing no new or enlarging lesions within 42 days prior to registration. These participants must also be neurologically asymptomatic and without corticosteroid treatment for at least 7 days prior to registration. Metastatic brain parenchymal disease must have been treated and participant must be off steroids for 7 days prior to registration. The presence of leptomeningeal disease (LMD) is not considered stable disease, and participants with LMD are not eligible for this study * Participants with known evidence of chronic hepatitis B virus (HBV) infection must have undetectable HBV viral load on suppressive therapy within 28 days prior to registration * Participants with a history of hepatitis C virus (HCV) infection must have been treated and cured. Participants with HCV infection who are currently on treatment must have an undetectable HCV viral load within 28 days prior to registration * Participants must have had one or two prior regimens of systemic chemotherapy for metastatic or locally advanced, unresectable disease. (A maintenance regimen of 5-fluorouracil or capecitabine, with or without bevacizumab, should not be counted as a separate line of treatment. The re-introduction of an initially successful induction regimen will not be counted as one additional line of treatment). Prior treatment for metastatic disease is not required for patients who experienced disease recurrence during or within 6 months of completion of adjuvant chemotherapy * Participants must be of age \>= 18 years at the time of informed consent * Participants must have a Zubrod performance status of 0 or 1 * Participants must have a complete medical history and physical exam within 28 days prior to registration * Absolute neutrophil count \>= 1.0 x 10\^3/uL (within 28 days prior to registration) * Hemoglobin \>= 9 g/dL (within 28 days prior to registration) * Platelets \>= 75 x 10\^3/uL (within 28 days prior to registration) * Total bilirubin =\< 1.5 x institutional upper limit of normal (ULN) (within 28 days prior to registration) * Aspartate aminotransferase (AST)/alanine aminotransferase (ALT) =\< 3 x institutional ULN (within 28 days prior to registration) * If liver metastases are present, then it is acceptable for AST level =\< 5.0 x ULN, and/or an ALT level =\< 5.0 x ULN (within 28 days prior to registration) * Participants must have serum creatinine =\< the IULN OR measured OR calculated creatinine clearance \>= 50 mL/min using the Cockroft-Gault Formula. This specimen must have been drawn and processed within 28 days prior to registration * Participants must be able to swallow and retain pills * Participants must have adequate cardiac function. Participants with known history or current symptoms of cardiac disease, or history of treatment with cardiotoxic agents, must have a clinical risk assessment of cardiac function using the New York Heart Association Functional Classification. To be eligible for this trial, participants must be class 2 or better * Participants with a known significant risk of corrected QT interval (QTc) prolongation must have an electrocardiogram (ECG) performed within 28 days prior to prior to registration * Note: Per package insert for encorafenib, participants already at risk for development of QTc prolongation include those who "already have or who are at significant risk of developing QTc prolongation, including participants with known long QT syndromes, clinically significant bradyarrhythmias, severe or uncontrolled heart failure and those taking other medicinal products associated with QT prolongation." * Participants must be offered the opportunity to participate in specimen banking. With participant consent, specimens must be collected and submitted via the Southwest Oncology Group (SWOG) Specimen Tracking System * Participants must be informed of the investigational nature of this study and must sign and give informed consent in accordance with institutional and federal guidelines. * Note: As a part of the OPEN registration process, the treating institution's identity is provided in order to ensure that the current (within 365 days) date of institutional review board approval for this study has been entered in the system Exclusion Criteria: * Participants must not have a known positive serology for human immunodeficiency virus (HIV). Encorafenib is contraindicated with concomitant use of non-nucleoside analog reverse transcriptase inhibitors like efavirenz and etravirine. In addition, it is recommended in the investigator brochure of encorafenib to avoid using encorafenib with protease inhibitors. Therefore, because all participants on this study would receive encorafenib for either randomized arm of treatment, participants with HIV who receive these components of highly active antiretroviral therapy (HAART) would be at high risk for complications of drug-drug interaction * Participants must not have had prior treatment with a BRAF inhibitor (including, but not limited to, encorafenib, dabrafenib, or vemurafenib), MEK inhibitor (including, but not limited to, trametinib, selumetinib, or binimetinib), or ERK inhibitor (of note, regorafenib is not considered a BRAF inhibitor for the context of eligibility criteria) * Participants must not have had prior treatment with anti-EGFR therapies * Participants must not have had prior treatment with an anti-PD-1, anti-PD-L1, anti-PD-L2, anti-CTLA-4 antibody, or any other antibody or drug specifically targeting T-cell co-stimulation or immune checkpoint pathways * Participants must not have a condition requiring systemic treatment with either corticosteroids (\> 10 mg daily prednisone equivalents) or other immunosuppressive medications within 14 days of registration. Inhaled or topical steroids and adrenal replacement doses \< 10 mg daily prednisone equivalents are permitted in the absence of active autoimmune disease. Patients are permitted to use topical, ocular, intra-articular, intranasal, and inhalational corticosteroids (with minimal systemic absorption). Physiologic replacement doses of systemic corticosteroids are permitted, even if \< 10 mg/day prednisone equivalents. A brief course of corticosteroids for prophylaxis (e.g., contrast dye allergy) or for treatment of non-autoimmune conditions (e.g., delayed-type hypersensitivity reaction caused by contact allergen) is permitted, as long as there has been a washout period for corticosteroids of \>= 7 days prior to registration * Participants must not have received a live vaccine within 30 days prior to study registration. Seasonal flu and COVID vaccines that do not contain a live virus are permitted * Participants must not be receiving any other investigational agents * Participants must not have impaired gastrointestinal function or disease that may significantly alter the absorption of study drug (e.g., ulcerative diseases, uncontrolled vomiting, malabsorption syndrome, small bowel resection with decreased intestinal absorption) * Participants must not have a history of inflammatory bowel disease, (including ulcerative colitis and Crohn's disease), symptomatic autoimmune disease (e.g., rheumatoid arthritis, systemic progressive sclerosis \[scleroderma\], systemic lupus erythematosus, autoimmune vasculitis \[e.g., Wegener's Granulomatosis\]); central nervous system (CNS) or motor neuropathy considered of autoimmune origin (e.g., Guillain-Barre Syndrome and myasthenia gravis, multiple sclerosis). * Note: Participants with Graves' disease will be allowed * Participants must not have a history of pneumonitis that has required oral or intravenous (IV) steroids within the last 12 months * Participants must not have a history of a grade 3 or 4 allergic reaction attributed to humanized or human monoclonal antibody therapy * Participants must not have a history of a prior allogeneic tissue or solid organ transplant * Participants must not have a history of acute coronary syndromes (including myocardial infarction, unstable angina, coronary artery bypass grafting, coronary angioplasty, or stenting) within 6 months prior to study registration * Participants must not have uncontrolled blood pressure and hypertension within 28 days prior to registration. * Uncontrolled blood pressure and hypertension is defined as systolic blood pressure (SBP) \>= 160 mmHg or diastolic blood pressure (DBP) \> 100 mmHg within 28 days prior to registration. Participants are permitted to be receiving multiple anti-hypertensive medications (unless otherwise indicated in the study). All blood pressure measurements within the 28 days prior to registration must be SBP \< 160 and DBP =\< 100. An exception can be made by a healthcare provider for a participant with a single blood pressure elevation who upon rechecking has a normal blood pressure * Participants must not have a prior or concurrent malignancy whose natural history or treatment (in the opinion of the treating physician) has the potential to interfere with the safety or efficacy assessment of the investigational regimen or requires concurrent therapy * Participants must not be pregnant or nursing. Individuals who are of reproductive potential must have agreed to use an effective contraceptive method with details provided as a part of the consent process. A person who has had menses at any time in the preceding 12 consecutive months or who has semen likely to contain sperm is considered to be of "reproductive potential." In addition to routine contraceptive methods, "effective contraception" also includes refraining from sexual activity that might result in pregnancy and surgery intended to prevent pregnancy (or with a side-effect of pregnancy prevention) including hysterectomy, bilateral oophorectomy, bilateral tubal ligation/occlusion and vasectomy with testing showing no sperm in the semen * Participants must not be planning treatment with other systemic anti-cancer agents (e.g., chemotherapy, hormonal therapy, immunotherapy) or other treatments not part of protocol-specified anti-cancer therapy including concurrent investigational agents of any type

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Conditions

The condition(s) this trial relates to.

colon adenocarcinoma colonic neoplasm colorectal cancer colorectal carcinoma malignant colon neoplasm rectal cancer rectal carcinoma rectal neoplasm rectum adenocarcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Metastatic colon adenocarcinoma Metastatic rectal adenocarcinoma Stage III colon cancer ajcc V8 Stage III rectal cancer ajcc V8 Stage IV colon cancer ajcc V8 Stage IV rectal cancer ajcc V8 Unresectable colon adenocarcinoma Unresectable rectal adenocarcinoma

Contacts and locations

Locations

AMG Crystal Lake - Oncology

Crystal Lake, Illinois, 60014, United States
AMG Libertyville - Oncology

Libertyville, Illinois, 60048, United States
Abbott-Northwestern Hospital

Minneapolis, Minnesota, 55407, United States
Adena Regional Medical Center

Chillicothe, Ohio, 45601, United States
Advocate Christ Medical Center

Oak Lawn, Illinois, 60453-2699, United States
Advocate Good Samaritan Hospital

Downers Grove, Illinois, 60515, United States
Advocate Good Shepherd Hospital

Barrington, Illinois, 60010, United States
Advocate Illinois Masonic Medical Center

Chicago, Illinois, 60657, United States
Advocate Lutheran General Hospital

Park Ridge, Illinois, 60068, United States
Advocate Sherman Hospital

Elgin, Illinois, 60123, United States
Advocate South Suburban Hospital

Hazel Crest, Illinois, 60429, United States
Atrium Medical Center-Middletown Regional Hospital

Franklin, Ohio, 45005-1066, United States
Aurora Bay Area Medical Group-Marinette

Marinette, Wisconsin, 54143, United States
Aurora BayCare Medical Center

Green Bay, Wisconsin, 54311, United States
Aurora Cancer Care-Grafton

Grafton, Wisconsin, 53024, United States
Aurora Cancer Care-Kenosha South

Kenosha, Wisconsin, 53142, United States
Aurora Cancer Care-Milwaukee

Milwaukee, Wisconsin, 53209, United States
Aurora Cancer Care-Milwaukee West

Wauwatosa, Wisconsin, 53226, United States
Aurora Cancer Care-Racine

Racine, Wisconsin, 53406, United States
Aurora Cancer Care-Southern Lakes VLCC

Burlington, Wisconsin, 53105, United States
Aurora Health Care Germantown Health Center

Germantown, Wisconsin, 53022, United States
Aurora Medical Center in Summit

Summit, Wisconsin, 53066, United States
Aurora Saint Luke's Medical Center

Milwaukee, Wisconsin, 53215, United States
Aurora Saint Luke's South Shore

Cudahy, Wisconsin, 53110, United States
Aurora Sinai Medical Center

Milwaukee, Wisconsin, 53233, United States
Aurora West Allis Medical Center

West Allis, Wisconsin, 53227, United States
Beacon Kalamazoo Cancer Center

Kalamazoo, Michigan, 49009, United States
Benefis Sletten Cancer Institute

Great Falls, Montana, 59405, United States
Bhadresh Nayak MD PC-Sterling Heights

Sterling Heights, Michigan, 48312, United States
Billings Clinic Cancer Center

Billings, Montana, 59101, United States
Bozeman Health Deaconess Hospital

Bozeman, Montana, 59715, United States
Bronson Battle Creek

Battle Creek, Michigan, 49017, United States
Bronson Methodist Hospital

Kalamazoo, Michigan, 49007, United States
CTCA at Southeastern Regional Medical Center

Newnan, Georgia, 30265, United States
CTCA at Western Regional Medical Center

Goodyear, Arizona, 85338, United States
Cancer Care Center of O'Fallon

O'Fallon, Illinois, 62269, United States
Cancer Care Specialists of Illinois - Decatur

Decatur, Illinois, 62526, United States
Cancer Care and Hematology-Fort Collins

Fort Collins, Colorado, 80528, United States
Cancer Center of Western Wisconsin

New Richmond, Wisconsin, 54017, United States
Cancer Centers of Southwest Oklahoma Research

Lawton, Oklahoma, 73505, United States
Cancer Hematology Centers - Flint

Flint, Michigan, 48503, United States
Cancer and Hematology Centers of Western Michigan - Norton Shores

Norton Shores, Michigan, 49444, United States
Carle Cancer Center

Urbana, Illinois, 61801, United States
Carle Physician Group-Effingham

Effingham, Illinois, 62401, United States
Carle Physician Group-Mattoon/Charleston

Mattoon, Illinois, 61938, United States
Carle at The Riverfront

Danville, Illinois, 61832, United States
Centralia Oncology Clinic

Centralia, Illinois, 62801, United States
Centro Comprensivo de Cancer de UPR

San Juan, 00927, Puerto Rico
Chelsea Hospital

Chelsea, Michigan, 48118, United States
Clackamas Radiation Oncology Center

Clackamas, Oregon, 97015, United States
Columbus Oncology and Hematology Associates

Dublin, Ohio, 43016, United States
Columbus Oncology and Hematology Associates Inc

Columbus, Ohio, 43214, United States
Community Hospital of Anaconda

Anaconda, Montana, 59711, United States
Community Medical Center

Missoula, Montana, 59804, United States
Condell Memorial Hospital

Libertyville, Illinois, 60048, United States
Corewell Health Grand Rapids Hospitals - Butterworth Hospital

Grand Rapids, Michigan, 49503, United States
Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center

Saint Joseph, Michigan, 49085, United States
Corewell Health Lakeland Hospitals - Niles Hospital

Niles, Michigan, 49120, United States
Corewell Health Reed City Hospital

Reed City, Michigan, 49677, United States
Crossroads Cancer Center

Effingham, Illinois, 62401, United States
Dartmouth Cancer Center - North

Saint Johnsbury, Vermont, 05819, United States
Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center

Lebanon, New Hampshire, 03756, United States
Dayton Physician LLC - Englewood

Dayton, Ohio, 45415, United States
Dayton Physicians LLC-Atrium

Franklin, Ohio, 45005, United States
Decatur Memorial Hospital

Decatur, Illinois, 62526, United States
Delaware Health Center-Grady Cancer Center

Delaware, Ohio, 43015, United States
Doctors Hospital

Columbus, Ohio, 43228, United States
Duluth Clinic Ashland

Ashland, Wisconsin, 54806, United States
Essentia Health - Deer River Clinic

Deer River, Minnesota, 56636, United States
Essentia Health Cancer Center

Duluth, Minnesota, 55805, United States
Essentia Health Hibbing Clinic

Hibbing, Minnesota, 55746, United States
Essentia Health Sandstone

Sandstone, Minnesota, 55072, United States
Essentia Health Virginia Clinic

Virginia, Minnesota, 55792, United States
Fairfield Medical Center

Lancaster, Ohio, 43130, United States
Fairview Southdale Hospital

Edina, Minnesota, 55435, United States
FirstHealth of the Carolinas-Moore Regional Hospital

Pinehurst, North Carolina, 28374, United States
Franciscan Health Indianapolis

Indianapolis, Indiana, 46237, United States
Franciscan Health Mooresville

Mooresville, Indiana, 46158, United States
Franciscan Saint Elizabeth Health - Lafayette East

Lafayette, Indiana, 47905, United States
Genesee Hematology Oncology PC

Flint, Michigan, 48503, United States
Genesis Healthcare System Cancer Care Center

Zanesville, Ohio, 43701, United States
Genesys Hurley Cancer Institute

Flint, Michigan, 48503, United States
Grady Memorial Hospital

Delaware, Ohio, 43015, United States
Grant Medical Center

Columbus, Ohio, 43215, United States
Henry Ford Health Providence Novi Hospital

Novi, Michigan, 48374, United States
Henry Ford Health Providence Southfield Hospital

Southfield, Michigan, 48075, United States
Henry Ford Health Saint John Hospital

Detroit, Michigan, 48236, United States
Henry Ford Health Warren Hospital

Warren, Michigan, 48093, United States
Henry Ford Hospital

Detroit, Michigan, 48202, United States
Henry Ford Medical Center-Columbus

Novi, Michigan, 48377, United States
Henry Ford River District Hospital

East China Township, Michigan, 48054, United States
Henry Ford Saint John Hospital - Academic

Grosse Pointe Woods, Michigan, 48236, United States
Henry Ford Saint John Hospital - Macomb Medical

Macomb, Michigan, 48044, United States
Henry Ford Saint John Hospital - Van Elslander

Grosse Pointe Woods, Michigan, 48236, United States
Henry Ford Warren Hospital - GLCMS

Warren, Michigan, 48093, United States
Henry Ford West Bloomfield Hospital

West Bloomfield, Michigan, 48322, United States
Hunterdon Medical Center

Flemington, New Jersey, 08822, United States
Huntsman Cancer Institute/University of Utah

Salt Lake City, Utah, 84112, United States
Hurley Medical Center

Flint, Michigan, 48503, United States
Huron Gastroenterology PC

Ypsilanti, Michigan, 48106, United States
Illinois CancerCare - Washington

Washington, Illinois, 61571, United States
Illinois CancerCare-Bloomington

Bloomington, Illinois, 61704, United States
Illinois CancerCare-Canton

Canton, Illinois, 61520, United States
Illinois CancerCare-Carthage

Carthage, Illinois, 62321, United States
Illinois CancerCare-Dixon

Dixon, Illinois, 61021, United States
Illinois CancerCare-Eureka

Eureka, Illinois, 61530, United States
Illinois CancerCare-Galesburg

Galesburg, Illinois, 61401, United States
Illinois CancerCare-Kewanee Clinic

Kewanee, Illinois, 61443, United States
Illinois CancerCare-Macomb

Macomb, Illinois, 61455, United States
Illinois CancerCare-Ottawa Clinic

Ottawa, Illinois, 61350, United States
Illinois CancerCare-Pekin

Pekin, Illinois, 61554, United States
Illinois CancerCare-Peoria

Peoria, Illinois, 61615, United States
Illinois CancerCare-Peru

Peru, Illinois, 61354, United States
Illinois CancerCare-Princeton

Princeton, Illinois, 61356, United States
Kaiser Permanente Downtown Commons

Sacramento, California, 95814, United States
Kaiser Permanente Dublin

Dublin, California, 94568, United States
Kaiser Permanente Medical Center - Santa Clara

Santa Clara, California, 95051, United States
Kaiser Permanente Moanalua Medical Center

Honolulu, Hawaii, 96819, United States
Kaiser Permanente San Leandro

San Leandro, California, 94577, United States
Kaiser Permanente-Fremont

Fremont, California, 94538, United States
Kaiser Permanente-Fresno

Fresno, California, 93720, United States
Kaiser Permanente-Modesto

Modesto, California, 95356, United States
Kaiser Permanente-Oakland

Oakland, California, 94611, United States
Kaiser Permanente-Roseville

Roseville, California, 95661, United States
Kaiser Permanente-San Francisco

San Francisco, California, 94115, United States
Kaiser Permanente-Santa Rosa

Santa Rosa, California, 95403, United States
Kaiser Permanente-Santa Teresa-San Jose

San Jose, California, 95119, United States
Kaiser Permanente-South Sacramento

Sacramento, California, 95823, United States
Kaiser Permanente-South San Francisco

South San Francisco, California, 94080, United States
Kaiser Permanente-Vallejo

Vallejo, California, 94589, United States
Kaiser Permanente-Walnut Creek

Walnut Creek, California, 94596, United States
Kettering Medical Center

Kettering, Ohio, 45429, United States
Knox Community Hospital

Mount Vernon, Ohio, 43050, United States
Kootenai Clinic Cancer Services - Post Falls

Post Falls, Idaho, 83854, United States
Kootenai Clinic Cancer Services - Sandpoint

Sandpoint, Idaho, 83864, United States
Kootenai Health - Coeur d'Alene

Coeur d'Alene, Idaho, 83814, United States
LSU Health Baton Rouge-North Clinic

Baton Rouge, Louisiana, 70805, United States
Lehigh Valley Hospital - Muhlenberg

Bethlehem, Pennsylvania, 18017, United States
Lehigh Valley Hospital-Cedar Crest

Allentown, Pennsylvania, 18103, United States
Licking Memorial Hospital

Newark, Ohio, 43055, United States
Logan Health Medical Center

Kalispell, Montana, 59901, United States
Macomb Hematology Oncology PC

Warren, Michigan, 48093, United States
Marshfield Medical Center - Minocqua

Minocqua, Wisconsin, 54548, United States
Marshfield Medical Center - Weston

Weston, Wisconsin, 54476, United States
Marshfield Medical Center-EC Cancer Center

Eau Claire, Wisconsin, 54701, United States
Marshfield Medical Center-Marshfield

Marshfield, Wisconsin, 54449, United States
Marshfield Medical Center-Rice Lake

Rice Lake, Wisconsin, 54868, United States
Marshfield Medical Center-River Region at Stevens Point

Stevens Point, Wisconsin, 54482, United States
Mary Greeley Medical Center

Ames, Iowa, 50010, United States
McFarland Clinic - Ames

Ames, Iowa, 50010, United States
McFarland Clinic - Boone

Boone, Iowa, 50036, United States
McFarland Clinic - Jefferson

Jefferson, Iowa, 50129, United States
McFarland Clinic - Marshalltown

Marshalltown, Iowa, 50158, United States
McFarland Clinic - Trinity Cancer Center

Fort Dodge, Iowa, 50501, United States
Medical Center of the Rockies

Loveland, Colorado, 80538, United States
Medical University of South Carolina

Charleston, South Carolina, 29425, United States
Memorial Hospital

Marysville, Ohio, 43040, United States
Memorial Hospital North

Colorado Springs, Colorado, 80920, United States
Mercy Cancer Center - Carmichael

Carmichael, California, 95608, United States
Mercy Cancer Center - Elk Grove

Elk Grove, California, 95758, United States
Mercy Cancer Center - Rocklin

Rocklin, California, 95765, United States
Mercy Cancer Center - Sacramento

Sacramento, California, 95816, United States
Mercy Hospital

Coon Rapids, Minnesota, 55433, United States
Mercy Hospital Oklahoma City

Oklahoma City, Oklahoma, 73120, United States
Mercy Medical Center - Des Moines

Des Moines, Iowa, 50314, United States
Mercy San Juan Medical Center

Carmichael, California, 95608, United States
Miami Valley Cancer Care and Infusion

Greenville, Ohio, 45331, United States
Miami Valley Hospital

Dayton, Ohio, 45409, United States
Miami Valley Hospital North

Dayton, Ohio, 45415, United States
Miami Valley Hospital South

Centerville, Ohio, 45459, United States
Mount Carmel East Hospital

Columbus, Ohio, 43213, United States
Mount Carmel Grove City Hospital

Grove City, Ohio, 43123, United States
Munson Medical Center

Traverse City, Michigan, 49684, United States
MyMichigan Medical Center Saginaw

Saginaw, Michigan, 48601, United States
MyMichigan Medical Center Tawas

Tawas City, Michigan, 48764, United States
North Memorial Medical Health Center

Robbinsdale, Minnesota, 55422, United States
Northwest Cancer Center - Crown Point

Crown Point, Indiana, 46307, United States
Northwest Cancer Center - Hobart

Hobart, Indiana, 46342, United States
Northwest Cancer Center - Valparaiso

Valparaiso, Indiana, 46383, United States
Northwest Oncology LLC

Dyer, Indiana, 46311, United States
Ochsner Hematology Oncology North Shore - Covington (West Region)

Covington, Louisiana, 70433, United States
Ochsner Medical Center Jefferson

New Orleans, Louisiana, 70121, United States
OhioHealth Mansfield Hospital

Mansfield, Ohio, 44903, United States
OhioHealth Marion General Hospital

Marion, Ohio, 43302, United States
Oncology Hematology Associates of Saginaw Valley PC

Saginaw, Michigan, 48604, United States
Our Lady of the Lake Physician Group

Baton Rouge, Louisiana, 70808, United States
PROncology

San Juan, 00927, Puerto Rico
Park Nicollet Clinic - Saint Louis Park

Saint Louis Park, Minnesota, 55416, United States
Poudre Valley Hospital

Fort Collins, Colorado, 80524, United States
Premier Blood and Cancer Center

Dayton, Ohio, 45409, United States
Prisma Health Cancer Institute - Butternut

Greenville, South Carolina, 29605, United States
Prisma Health Cancer Institute - Easley

Easley, South Carolina, 29640, United States
Prisma Health Cancer Institute - Eastside

Greenville, South Carolina, 29615, United States
Prisma Health Cancer Institute - Faris

Greenville, South Carolina, 29605, United States
Prisma Health Cancer Institute - Greer

Greer, South Carolina, 29650, United States
Prisma Health Cancer Institute - Seneca

Seneca, South Carolina, 29672, United States
Prisma Health Cancer Institute - Spartanburg

Boiling Springs, South Carolina, 29316, United States
Prisma Health Greenville Memorial Hospital

Greenville, South Carolina, 29605, United States
ProHealth D N Greenwald Center

Mukwonago, Wisconsin, 53149, United States
ProHealth Oconomowoc Memorial Hospital

Oconomowoc, Wisconsin, 53066, United States
Providence Cancer Institute Clackamas Clinic

Clackamas, Oregon, 97015, United States
Providence Newberg Medical Center

Newberg, Oregon, 97132, United States
Providence Portland Medical Center

Portland, Oregon, 97213, United States
Providence Saint Vincent Medical Center

Portland, Oregon, 97225, United States
Providence Willamette Falls Medical Center

Oregon City, Oregon, 97045, United States
Puerto Rico Hematology Oncology Group

Bayamón, 00961, Puerto Rico
Reading Hospital

West Reading, Pennsylvania, 19611, United States
Regions Hospital

Saint Paul, Minnesota, 55101, United States
Rhode Island Hospital

Providence, Rhode Island, 02903, United States
Riverside Methodist Hospital

Columbus, Ohio, 43214, United States
Rocky Mountain Cancer Centers-Penrose

Colorado Springs, Colorado, 80907, United States
Roswell Park Cancer Institute

Buffalo, New York, 14263, United States
Rush-Copley Healthcare Center

Yorkville, Illinois, 60560, United States
Rush-Copley Medical Center

Aurora, Illinois, 60504, United States
Saint Alphonsus Cancer Care Center-Boise

Boise, Idaho, 83706, United States
Saint Alphonsus Cancer Care Center-Caldwell

Caldwell, Idaho, 83605, United States
Saint Alphonsus Cancer Care Center-Nampa

Nampa, Idaho, 83687, United States
Saint Alphonsus Cancer Care Center-Ontario

Ontario, Oregon, 97914, United States
Saint Ann's Hospital

Westerville, Ohio, 43081, United States
Saint Catherine Hospital

Indianapolis, Indiana, 46312, United States
Saint Francis Medical Center

Cape Girardeau, Missouri, 63703, United States
Saint Luke's Cancer Institute - Boise

Boise, Idaho, 83712, United States
Saint Luke's Cancer Institute - Fruitland

Fruitland, Idaho, 83619, United States
Saint Luke's Cancer Institute - Meridian

Meridian, Idaho, 83642, United States
Saint Luke's Cancer Institute - Nampa

Nampa, Idaho, 83687, United States
Saint Luke's Cancer Institute - Twin Falls

Twin Falls, Idaho, 83301, United States
Saint Mary Medical Center

Hobart, Indiana, 46342, United States
Saint Mary's Oncology/Hematology Associates of West Branch

West Branch, Michigan, 48661, United States
San Juan City Hospital

San Juan, 00936, Puerto Rico
Southeastern Medical Oncology Center-Clinton

Clinton, North Carolina, 28328, United States
Southeastern Medical Oncology Center-Goldsboro

Goldsboro, North Carolina, 27534, United States
Southeastern Medical Oncology Center-Jacksonville

Jacksonville, North Carolina, 28546, United States
Southern Illinois University School of Medicine

Springfield, Illinois, 62702, United States
Southern Ohio Medical Center

Portsmouth, Ohio, 45662, United States
Springfield Clinic

Springfield, Illinois, 62702, United States
Springfield Memorial Hospital

Springfield, Illinois, 62781, United States
Springfield Regional Cancer Center

Springfield, Ohio, 45504, United States
Springfield Regional Medical Center

Springfield, Ohio, 45504, United States
Strecker Cancer Center-Belpre

Belpre, Ohio, 45714, United States
Swedish Cancer Institute-Edmonds

Edmonds, Washington, 98026, United States
Swedish Cancer Institute-Issaquah

Issaquah, Washington, 98029, United States
Swedish Medical Center-First Hill

Seattle, Washington, 98122, United States
The Community Hospital

Munster, Indiana, 46321, United States
The Don and Sybil Harrington Cancer Center

Amarillo, Texas, 79106, United States
The Mark H Zangmeister Center

Columbus, Ohio, 43219, United States
ThedaCare Regional Cancer Center

Appleton, Wisconsin, 54911, United States
Toledo Clinic Cancer Centers-Toledo

Toledo, Ohio, 43623, United States
Trinity Health Grand Rapids Hospital

Grand Rapids, Michigan, 49503, United States
Trinity Health IHA Medical Group Hematology Oncology - Brighton

Brighton, Michigan, 48114, United States
Trinity Health IHA Medical Group Hematology Oncology - Canton

Canton, Michigan, 48188, United States
Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital

Chelsea, Michigan, 48118, United States
Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus

Ypsilanti, Michigan, 48197, United States
Trinity Health Medical Center - Brighton

Brighton, Michigan, 48114, United States
Trinity Health Medical Center - Canton

Canton, Michigan, 48188, United States
Trinity Health Muskegon Hospital

Muskegon, Michigan, 49444, United States
Trinity Health Saint Joseph Mercy Hospital Ann Arbor

Ann Arbor, Michigan, 48106, United States
Trinity Health Saint Mary Mercy Livonia Hospital

Livonia, Michigan, 48154, United States
UC Irvine Health/Chao Family Comprehensive Cancer Center

Orange, California, 92868, United States
UCHealth Greeley Hospital

Greeley, Colorado, 80631, United States
UCHealth Highlands Ranch Hospital

Highlands Ranch, Colorado, 80129, United States
UCHealth Memorial Hospital Central

Colorado Springs, Colorado, 80909, United States
UCHealth University of Colorado Hospital

Aurora, Colorado, 80045, United States
UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care

Irvine, California, 92612, United States
UT MD Anderson Cancer Center

Houston, Texas, 77030, United States
UT Southwestern Clinical Center at Richardson/Plano

Richardson, Texas, 75080, United States
UT Southwestern Simmons Cancer Center - RedBird

Dallas, Texas, 75237, United States
UT Southwestern/Simmons Cancer Center-Dallas

Dallas, Texas, 75390, United States
UT Southwestern/Simmons Cancer Center-Fort Worth

Fort Worth, Texas, 76104, United States
UW Cancer Center at ProHealth Care

Waukesha, Wisconsin, 53188, United States
United Hospital

Saint Paul, Minnesota, 55102, United States
United Hospital Center

Bridgeport, West Virginia, 26330, United States
University of Illinois

Chicago, Illinois, 60612, United States
University of Michigan Health - Sparrow Lansing

Lansing, Michigan, 48912, United States
University of Michigan Health - West

Wyoming, Michigan, 49519, United States
University of Oklahoma Health Sciences Center

Oklahoma City, Oklahoma, 73104, United States
University of Pennsylvania/Abramson Cancer Center

Philadelphia, Pennsylvania, 19104, United States
Upper Valley Medical Center

Troy, Ohio, 45373, United States
Vanderbilt University/Ingram Cancer Center

Nashville, Tennessee, 37232, United States
Vince Lombardi Cancer Clinic - Oshkosh

Oshkosh, Wisconsin, 54904, United States
Vince Lombardi Cancer Clinic-Sheboygan

Sheboygan, Wisconsin, 53081, United States
Vince Lombardi Cancer Clinic-Two Rivers

Two Rivers, Wisconsin, 54241, United States
West Michigan Cancer Center

Kalamazoo, Michigan, 49007, United States
West Virginia University Healthcare

Morgantown, West Virginia, 26506, United States
Women's Diagnostic Center - Munster

Munster, Indiana, 46321, United States
Woodland Cancer Care Center

Michigan City, Indiana, 46360, United States
Woodland Memorial Hospital

Woodland, California, 95695, United States

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