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Could a common drug ease swallowing trouble in brain disorders?

NCT ID NCT05551182

Symptom relief Sponsor: Phramongkutklao College of Medicine and Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at whether nicergoline, a drug that improves blood flow in the brain, can help people with swallowing problems caused by stroke, Parkinson's disease, or dementia. 92 adults were given either a low or high dose for 12 weeks. The goal was to see if swallowing improved and to find the best dose with the fewest side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

92 people

The number who actually took part.

Started

Jan 2023

Finished

Aug 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

20 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age greater than or equal to 20 years * Stroke (post events at least 2 months), Parkinson's disease and dementia patients who have dysphagia symptom * Do not take nicergoline prior recruit 2 weeks * Continue current medications * Consent to join Exclusion Criteria: * Allergy to gentamicin or components * On anticoagulants including Heparin, Enoxaparin, Fondaparinux, Warfarin, Dabigatran, Apixaban, Rivaroxaban and Edoxaban * On antiplatelet \> 1 drug (ex. dual antiplatelet) * On ACE-I or Dopaminergic agent 2 months or less * Chronic dyspepsia * Chronic gout or hyperuricemia \> 8 mg/dL * CrCl \< 30 ml/min * Impair hepatic function including child puge B, C or active hepatitis * Brainstem stroke * Parkinson plus syndrome: PSP, MSA, DLB, etc * Advanced cancer or other medical conditions * Bed ridden * Laryngopharynx surgery * SBP\<100 or DBP 60 mmHg * HR\<50/min * Active bleeding * Pregnancy or lactation * Known of poor compliance for any treatments

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Conditions

The condition(s) this trial relates to.

Deglutition Disorders dementia Parkinson disease stroke disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Dysphagia

Contacts and locations

Locations

  • Phramongkutklao Hospital

    Ratchathewi, Bangkok, 10400, Thailand

More trials for these conditions

Other studies related to the condition(s) this trial covers.