New scan could spot hidden cancers in the belly
NCT ID NCT07219238
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests a new PET/CT scan using a radioactive tracer called GEH300079 to detect peritoneal carcinomatosis—cancer that has spread to the lining of the abdomen—in people with colorectal, stomach, ovarian, or pancreatic cancer. About 175 adults with known or suspected spread will receive the scan before planned surgery. The goal is to see if this scan is more accurate than standard imaging at finding cancer in different abdominal regions.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- GEH300079 (68Ga) injection (a radioactive tracer used in PET/CT imaging)
- What this could lead to
- If successful, this could provide a more accurate, non-invasive way to detect cancer spread in the abdomen, helping doctors plan better surgeries.
- What could go wrong
- This is an early-to-mid-stage trial with only 175 participants, so results may not apply to all patients. The scan may not be more accurate than current methods.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Phase 2/3
Runs two stages together: whether the treatment works, then large-scale confirmation.
- Participants
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About 175 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Oct 2026
An estimate. Start dates often move.
- Expected to finish
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Aug 2029
An estimate. End dates often move.
- Lead sponsor
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A company
The lead sponsor is a pharmaceutical, biotech, or medical-device company.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Participant is ≥18 years of age * Participant has provided signed informed consent before any study-specific screening procedures * Participant has histopathologically confirmed primary colorectal, gastric or ovarian cancer or PDAC * Participant has known or suspected PC from the tumor of origin. Suspicion may be based on imaging or clinical findings. * Participant is scheduled for peritoneal surgery with curative intent, surgical exploration, or laparoscopy, with either: a. No neoadjuvant treatment received, treatment-naïve (i.e., undergoing upfront surgery or laparoscopy) b. Completed systemic treatment (which may include neoadjuvant chemotherapy) before GEH300079 ( 68Ga) PET/CT Imaging Visit * Participant has Eastern Cooperative Oncology Group (ECOG) performance status ≤2 * Participant is able and willing to comply with all study procedures as described in the protocol Exclusion Criteria: * Participant is pregnant or breast-feeding, or sexually active and not using or not willing to use an acceptable form of birth control from screening up to 30 days after receiving the investigational medicinal product (IMP) * Participant has a known disorder that, in the opinion of the investigator, will impact the study procedures * Participant needs any intervention that would delay study participation * Participant has non-resectable extra-abdominal metastasis and/or \>3 hepatic metastases on standard work up * Participant will not be able to complete the study, based on their anticipated life expectancy * Participant has active bacterial, viral, or fungal infection requiring systemic antibacterial, anti-viral or antifungal therapy (topical medications are permitted) * Participant has renal function impairment as defined by: 1. For Phase 2: estimated glomerular filtration rate less than 60 mL/min 2. For Phase 3: estimated glomerular filtration rate less than 30 mL/min * Participant has severe hepatic function impairment as defined by: 1. Aspartate aminotransferase (serum glutamic-oxaloacetic transaminase) and alanine aminotransferase (serum glutamic-pyruvic transaminase): ≤2.5 × upper limit of normal (ULN; ≤5 × ULN for participants with liver metastases) 2. Bilirubin: ≤1.5 × ULN or direct bilirubin ≤ULN for participants with total bilirubin levels \>1.5 × ULN * Participant has autoimmune disease that required systemic treatment in the past 2 years. Replacement therapy (e.g., thyroxine, insulin, or physiologic corticosteroid) is allowed * Participant has serious co-morbidities or serious non-malignant disease that in the opinion of the investigator, could compromise participant safety and/or protocol objectives * Participant either received or is planning to receive any other investigational agent within the 28 days prior to the first imaging visit or during study participation (with the exception of the 3-month follow-up period) * Participant has known or suspected hypersensitivity to any excipients used in GEH300079 (68Ga) * Participant has severe claustrophobia, is unable to lie flat or fit into the scanner, or is unable to tolerate the PET/CT scan for any reason * (Phase 3 only) Participant was previously included in Phase 2 of this study
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
2 sites in 2 countries. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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BAMF Health
NOT_YET_RECRUITINGGrand Rapids, Michigan, 49503, United States
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Karolinska Universitetssjukhuset
RECRUITINGStockholm, 17176, Sweden
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