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New hope for brain cancer: targeted drug combo tested in early trial

NCT ID NCT05739942

First seen Oct 31, 2025 · Last updated May 23, 2026 · Updated 33 times

Summary

This early-phase study tests a new drug, [177Lu]Lu-NeoB, in people with glioblastoma, a serious brain cancer. For newly diagnosed patients, the drug is given alongside standard radiation and chemotherapy. For those whose cancer has returned, it is given alone. The main goal is to find the safest dose and check for side effects. About 42 adults will take part.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • Dana Farber Cancer Institute

    Boston, Massachusetts, 02215, United States

  • Memorial Sloan Kettering Cancer Ctr

    New York, New York, 10065, United States

  • Novartis Investigative Site

    Dijon, Cote D Or, 21034, France

  • Novartis Investigative Site

    Essen, 45147, Germany

  • Novartis Investigative Site

    München, 80377, Germany

  • Novartis Investigative Site

    Reggio Emilia, RE, 42123, Italy

  • Novartis Investigative Site

    Porto, 4200-072, Portugal

  • Novartis Investigative Site

    Granada, Andalusia, 18014, Spain

  • Novartis Investigative Site

    Badalona, Barcelona, 08916, Spain

  • Novartis Investigative Site

    L'Hospitalet de Llobregat, Barcelona, 08907, Spain

  • Novartis Investigative Site

    Madrid, 28009, Spain

  • Novartis Investigative Site

    Madrid, 28040, Spain

  • Uni of Utah Huntsman Cancer Inst

    Salt Lake City, Utah, 84103, United States

  • Univ Hosp Cleveland Medical Center

    Cleveland, Ohio, 44106-5028, United States

  • University of California LA

    Los Angeles, California, 90095, United States

  • University of Colorado Denver

    Aurora, Colorado, 80045, United States

Conditions

Explore the condition pages connected to this study.