New combo attack on metastatic tumors shows promise in early trial

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age ≥18 years; * Histologically or cytologically confirmed solid malignancy with metastatic disease not amenable to curative surgery or definitive curative-intent radiotherapy; * High-burden metastatic disease, defined as: Multiple metastases: ≥3 metastatic lesions on imaging, and at least 2 measurable lesions (RECIST v1.1) planned as protocol target lesions; and Bulky lesion: at least 1 lesion meeting bulky criteria (e.g., longest diameter ≥7 cm or tumor volume ≥100 mL, per protocol) designated as the bulky index lesion; * At least 2 and up to 5 prespecified target lesions are suitable for protocol local therapy and can be assigned per protocol (lesion allocation and/or tumor zoning); * ECOG performance status 0-2; * Adequate organ function; * Willing and able to provide written informed consent. Exclusion Criteria: * Lesions requiring emergent surgical decompression or other urgent intervention that cannot be deferred to protocol timelines; * Target lesions not safely accessible for percutaneous cryoablation and/or 125I seed implantation (e.g., no feasible needle path, unacceptable risk to critical structures despite protective maneuvers); * Active, uncontrolled infection; uncontrolled pleural effusion/ascites requiring frequent drainage (unless stabilized); * Severe cardiopulmonary comorbidity prohibiting anesthesia/sedation or percutaneous intervention (e.g., unstable angina, recent MI, uncontrolled arrhythmia, severe COPD with high oxygen requirement); * Prior local therapy to the same bulky index lesion that would confound response assessment (prior treatment to other non-index lesions may be allowed); * Uncontrolled CNS metastases (symptomatic, requiring escalating steroids, or not stable after local therapy). Stable treated brain metastases may be allowed per protocol; * Any condition that, in the investigator's judgment, would compromise protocol compliance or make participation unsafe.