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Protein in blood may predict how seniors react to sedation

NCT ID NCT07280663

Knowledge-focused Sponsor: Second Hospital of Shanxi Medical University Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This completed early-phase study looked at 128 older adults (60+) having knee replacement surgery. Researchers measured a protein called neurofilament light chain in the blood and checked how sensitive patients were to the sedative remazolam. The goal was to see if higher protein levels—which can indicate nerve damage—relate to needing less sedation or having more side effects. The findings could help doctors personalize anesthesia for elderly patients, but the study is small and only explores a possible link, not a treatment.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Remazolam
What this could lead to
If successful, this could help anesthesiologists tailor sedation doses for older patients, potentially reducing risks like confusion or falls after surgery.
What could go wrong
This is a very early, small study (128 people) that only looks for a link between a protein and drug sensitivity. It does not test a new treatment, so direct benefits are uncertain.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Early phase 1

The earliest testing in people: a first look at safety, in a very small group.

Participants

128 people

The number who actually took part.

Started

Oct 2025

Finished

Oct 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

60 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Elective knee joint replacements. * Age ≥ 60 years. * ASA rating I \~ III. Exclusion Criteria: * Persons who have recently used sedatives or opioids. * Persons who are allergic to narcotic drugs. * People with clotting disorder, infection at the site of the puncture, spinal deformities or spinal disorders. * Those who have been diagnosed with nervous system disorders. * Patients or family members refuse to participate in this study. * Exit research for their own reasons.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Old age

Contacts and locations

Locations

  • Second Hospital of Shanxi Medical University

    Taiyuan, Shanxi, 030001, China

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