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New study aims to match neck pain patients with the right treatment faster

NCT ID NCT06906107

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Sep 15, 2026 · Updated 2 times

Summary

This study tests a method to identify which people with neck pain are most likely to get significant relief from a specific hands-on technique called cervical spine manipulation. Researchers will enroll 160 adults aged 18 to 70 with neck pain and randomly assign them to receive either manipulation or a gentle touch, followed by exercise for both groups. The goal is to see if the prediction method works across different clinics and therapists, helping doctors choose the best treatment for each patient.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 160 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jun 2025

Expected to finish

Mar 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 70 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Ages 18 to 70 * Primary complaint of neck pain with or without unilateral upper extremity symptoms * Neck Disability Index (NDI) score of 10 or greater * Numeric Pain Rating Scale score of 2 or greater Exclusion Criteria: * History of whiplash injury within the past 6 weeks * Diagnosis of cervical spinal stenosis * Bilateral upper extremity symptoms * Red flags noted in the patient's Neck Medical Screening Questionnaire (i.e. tumor, fracture, rheumatoid arthritis, osteoporosis, severe atherosclerosis, dizziness, diplopia, drop attacks, bilateral numbness, nausea, prolonged history of steroid use) * Evidence of central nervous system involvement, to include hyperreflexia, sensory disturbances in the hand, intrinsic muscle wasting of the hands, unsteadiness during walking, nystagmus, loss of visual acuity, impaired sensation of the face, altered taste, the presence of pathological reflexes (i.e. positive Hoffman's and/or Babinski reflexes) * Two or more positive neurological signs consistent with significant nerve root compression, including any two of the following: 1. Muscle weakness involving a major muscle group of the upper extremity 2. Diminished upper extremity muscle stretch reflex (biceps, triceps, or brachioradialis) 3. Diminished or absent sensation to pinprick or light touch in any upper extremity dermatome * Prior neck surgery * Current pregnancy, pregnancy within 6 months, or currently lactating * Pending legal action pertaining to their neck pain * Currently receiving manual therapy treatment for neck pain through chiropractic or physical therapy care * Inability to read English at the 8th grade reading level * Inability to legally provide informed consent for any other reason * Inability to comply with the treatment and follow-up schedule

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Conditions

The condition(s) this trial relates to.

Neck Pain

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • ActivePT

    Rochester, Minnesota, 55901, United States

  • ActiveTherapy Alliance

    Waco, Texas, 76798, United States

  • Emplify by Bellin Health Ashwaubenon

    Green Bay, Wisconsin, 54313, United States

  • PROActivePT

    Syracuse, New York, 13201, United States

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