New study aims to match neck pain patients with the right treatment faster
NCT ID NCT06906107
First seen Jun 27, 2026 · Last updated Sep 15, 2026 · Updated 2 times
Summary
This study tests a method to identify which people with neck pain are most likely to get significant relief from a specific hands-on technique called cervical spine manipulation. Researchers will enroll 160 adults aged 18 to 70 with neck pain and randomly assign them to receive either manipulation or a gentle touch, followed by exercise for both groups. The goal is to see if the prediction method works across different clinics and therapists, helping doctors choose the best treatment for each patient.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 160 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Jun 2025
- Expected to finish
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Mar 2027
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 70 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Ages 18 to 70 * Primary complaint of neck pain with or without unilateral upper extremity symptoms * Neck Disability Index (NDI) score of 10 or greater * Numeric Pain Rating Scale score of 2 or greater Exclusion Criteria: * History of whiplash injury within the past 6 weeks * Diagnosis of cervical spinal stenosis * Bilateral upper extremity symptoms * Red flags noted in the patient's Neck Medical Screening Questionnaire (i.e. tumor, fracture, rheumatoid arthritis, osteoporosis, severe atherosclerosis, dizziness, diplopia, drop attacks, bilateral numbness, nausea, prolonged history of steroid use) * Evidence of central nervous system involvement, to include hyperreflexia, sensory disturbances in the hand, intrinsic muscle wasting of the hands, unsteadiness during walking, nystagmus, loss of visual acuity, impaired sensation of the face, altered taste, the presence of pathological reflexes (i.e. positive Hoffman's and/or Babinski reflexes) * Two or more positive neurological signs consistent with significant nerve root compression, including any two of the following: 1. Muscle weakness involving a major muscle group of the upper extremity 2. Diminished upper extremity muscle stretch reflex (biceps, triceps, or brachioradialis) 3. Diminished or absent sensation to pinprick or light touch in any upper extremity dermatome * Prior neck surgery * Current pregnancy, pregnancy within 6 months, or currently lactating * Pending legal action pertaining to their neck pain * Currently receiving manual therapy treatment for neck pain through chiropractic or physical therapy care * Inability to read English at the 8th grade reading level * Inability to legally provide informed consent for any other reason * Inability to comply with the treatment and follow-up schedule
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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ActivePT
Rochester, Minnesota, 55901, United States
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ActiveTherapy Alliance
Waco, Texas, 76798, United States
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Emplify by Bellin Health Ashwaubenon
Green Bay, Wisconsin, 54313, United States
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PROActivePT
Syracuse, New York, 13201, United States
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Other studies related to the condition(s) this trial covers.
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