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Brain's pain switch may predict neck pain relief

NCT ID NCT07194603

Knowledge-focused Sponsor: Azusa Pacific University Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at 31 adults with chronic mild neck pain to see if a test called conditioned pain modulation (CPM) — which measures the brain's ability to turn down pain — could predict how well they respond to a common hands-on treatment called spinal mobilization. Participants received one session of neck mobilization and were followed for 4 weeks. The goal was to understand if baseline CPM or changes in CPM after treatment are linked to improvements in pain, disability, and perceived recovery.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this could help identify which patients with chronic neck pain are most likely to benefit from spinal mobilization, leading to more personalized treatment.
What could go wrong
This is a small, completed observational study (31 participants) with no control group. Results may not apply to everyone with neck pain, and the link between pain modulation and outcomes may be weak or absent.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

31 people

The number who actually took part.

Started

Jun 2021

Finished

Aug 2022

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 55 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * neck pain classified as Neck Pain and Associated Disorder I (NAD) I with a duration of 3-60 months * a 3 or higher pain scale rating out of 10 on the Numeric Pain Rating Scale * modified STarTBack tool (modified for neck pain) classified as low risk (\< 3 out of 9) * a Neck Disability Index scored at 10% or higher Exclusion Criteria: * prior spinal surgery, those with serious underlying pathology including neurologic, cardiovascular, hypertension, diabetes mellitus, inflammatory arthritis, osteoporosis, hemophilia, cancer, contra-indications to cervical spine joint mobilization (or spinal mobilization of the neck) \[e.g., a history of fainting spells or loss of consciousness, presently on blood thinners\] * those who received spinal mobilization of the neck (or cervical spine joint mobilization) or physical therapy prescribed exercise in the past 3 months, current smokers, those with chronic widespread pain, those actively pursuing compensation, unable to work or with litigation pending or unable to communicate in English, persons who cannot tolerate 2 minutes of the cold pressor test (12 degrees Centigrade).

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Conditions

The condition(s) this trial relates to.

Bronchiolitis Obliterans Syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Chronic Neck pain musculoskeletal

Contacts and locations

Locations

  • Azusa Pacific University

    Azusa, California, 91702, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.