Can an app replace the pill? 2,000 women test digital birth control
NCT ID NCT07566793
First seen Jun 27, 2026 · Last updated Jul 02, 2026 · Updated 2 times
Summary
This study is testing the Natural Cycles app, a digital birth control method that tracks your cycle to tell you when to avoid unprotected sex. About 2,000 women aged 18-35 will use the app as their only form of contraception for one year. Researchers will track how many get pregnant, both among typical users and those who follow the app's instructions perfectly.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Participants
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About 2,000 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Apr 2026
- Expected to finish
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Dec 2027
An estimate. End dates often move.
- Lead sponsor
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A company
The lead sponsor is a pharmaceutical, biotech, or medical-device company.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
New Natural Cycles application users living in the United States
- Ages
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18 to 35 years
- Sex
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Female participants only
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Wants to avoid pregnancy for 13 cycles. * Is willing to rely solely on Natural Cycles as their sole contraception method for 13 cycles. * Is not currently using permanent contraceptive methods, such as sterilization (of either the user or their partner), or hormonal methods, such as the hormonal contraceptive implant or IUD. * Has an intact uterus, both ovaries and both fallopian tubes to the best of their knowledge. * Has an average cycle length between 21 and 35 days. The user anticipates heterosexual intercourse at least once a month in the next year. * Is willing to enter data on a daily basis and perform pregnancy tests as requested by protocol. * Is willing to complete a satisfaction survey at the end of her study participation. Exclusion Criteria: * Has EU-citizenship * Has had a Depo-Provera injection in the last 10 months or has had less than three consecutive, spontaneous menstrual cycles since their last injection. * Has had less than three consecutive, spontaneous menstrual cycles after removing a hormonal implant. * Has had less than three consecutive, spontaneous menstrual cycles after the end of a pregnancy. * Has had less than three consecutive, spontaneous menstrual cycles since she last breastfed. * Has (or partner has) known fertility issues, such as infertility and sterilization, or have been advised by a healthcare professional that they may have difficulty conceiving for any reason. * Has a medical condition possibly impacting fertility, i.e. endometriosis, a history of Pelvic Inflammatory Disease (PID), significant uterine fibroids or adenomyosis, or another diagnosed medical condition that they have been told affects fertility. * Is regularly taking one of the following prescribed pharmaceutical medications known to be teratogenic (i.e., a medication that can cause birth defects): Isotretinoin (like Accutane, Absorica, Claravis, or Myorisan) for severe acne Valproic acid or divalproex sodium (like Depakote, Depakene, or Topamax) for seizures (epilepsy), migraines, or bipolar disorder Methotrexate (Trexall, Rheumatrex) or leflunomide (Arava) for autoimmune conditions ACE Inhibitors (like Lisinopril, Enalapril) or Angiotensin II Receptor Blockers (ARBs) (like Losartan, Valsartan) for high blood pressure or heart conditions Warfarin (Coumadin, Jantoven) for blood clot prevention
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Natural Cycles USA Corp
RECRUITINGNew York, New York, 10036, United States
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- Can a redesigned IUD inserter make birth control safer and easier?
- Texts and local mentors: a new way to empower teen girls on contraception?
- Could a single implant replace the morning-after pill?