Could supermarket peanuts and milk cure food allergies? new study investigates.

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Age 6-23 years with IgE-mediated peanut allergy, or age 3-23 years with IgE-mediated food allergy to cow's milk 2. Past history consistent with IgE-mediated allergy to the relevant allergen 3. Allergic to cumulative ≤1.44 g protein (of the specific allergen) at baseline DBPCFC, prior to treatment allocation 4. Written informed consent (for young people under 16, consent from the parent/legal guardian (AND assent from the young person when the young person is age 6+ years) Exclusion Criteria: 1. Required previous admission to an intensive care unit for management of an allergic reaction 2. Clinically significant chronic illness (other than asthma, rhinitis or eczema) 3. Moderate-severe eczema, defined as requiring more than once daily application of 1% hydrocortisone or equivalent topical calcineurin inhibitor as maintenance treatment despite appropriate use of emollients (eczema is not otherwise an exclusion criteria) 4. Poorly controlled asthma within the previous 3 months (as defined by clinician judgement with reference to the International Consensus On (ICON) Pediatric Asthma consensus), or asthma requiring treatment with \>5 days oral corticosteroids within the previous 3 months 5. Previous history of eosinophilic oesophagitis 6. Undergoing subcutaneous or sublingual immunotherapy to respiratory allergens, and not yet established on maintenance dosing for at least 6 months 7. Undergoing allergen immunotherapy for food allergy and within the first year of treatment 8. In CM-allergic children under consideration for desensitisation to CM: * currently consuming CM-containing products other than extensively-heated milk in baked foods (e.g. biscuits, cakes) * significant symptoms of non-IgE-mediated CM allergy within the previous 12 months 9. Taking prebiotic or probiotic supplements and unwillingness to discontinue 10. Subjects receiving anti-IgE therapy, oral immunosuppressants, beta-blocker or Angiotensin Converting Enzyme (ACE) inhibitor 11. Tolerance to cumulative ≥1.44 g food protein at initial DBPCFC during screening 12. Objective allergic reaction to ≤4mg cow's milk protein or ½ Reese's puff in peanut-allergic children, during screening 13. Objective reaction to the placebo at screening DBPCFC 14. Past or current medical issue, participation in another clinical trial or other consideration, which, in the opinion of the investigator, may pose additional risks from study participation, interfere with compliance or otherwise impact on the quality or interpretation of study data 15. Pregnancy 16. Direct personal or commercial relationship with a member of the local study team directly involved with the conduct of the trial 17. Unwilling or unable to fulfil study requirements, including the requirement for appropriate supervision following dosing at home)