Mucus-Busting asthma trial fizzles out

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Male or female between the ages of 18 and 80 years of age at Visit 1 2. Written informed consent obtained from subject and ability for subject to comply with the requirements of the study. 3. Able to perform reproducible spirometry according to American Thoracic Society (ATS) criteria 4. Physiological evidence of airflow obstruction (FEV1 bronchodilator reversibility of ≥ 12% or hyperreactivity to methacholine reflected by a methacholine provocative concentration that results in a 20% fall in FEV1(PC20) ≤ 16 mg/mL) 5. Clinical history of asthma per patient report or medical record 6. Pre-bronchodilator FEV1 \> 35% predicted 7. Post-bronchodilator FEV1 \> 40% but \< 90% predicted 8. Asthma requiring treatment with inhaled corticosteroids (ICS) for 3 months or greater 9. CT mucus score ≥ 5 10. Ability to tolerate study drug reflected by a post-treatment FEV1 ≥ 80% of pre- treatment, pre-bronchodilator FEV1 Exclusion Criteria: 1. Pregnant, breastfeeding, or unwilling to practice birth control during participation in the study 2. Presence of a condition or abnormality that in the opinion of the Investigator would compromise the safety of the patient or the quality of the data 3. Smoking of tobacco or other recreational inhalants in last year and/or \>10 pack-year smoking history 4. Adherence to study drug ≤ 70% after first treatment period 5. Current participation in an investigational drug trial 6. Other chronic pulmonary disorders, including (but not limited to) cystic fibrosis, chronic obstructive pulmonary disease, chronic bronchitis, vocal cord dysfunction (that is the sole cause of respiratory symptoms and at the PI's discretion), severe scoliosis or chest wall deformities that affect lung function, or congenital disorders of the lungs or airways 7. Unwillingness to follow study procedures 8. History of allergy or intolerance to study drug 9. Any other criteria that places the subject at unnecessary risk according to the judgment of the Principal Investigator