Robotic arm brace could restore movement in chronic stroke patients
NCT ID NCT05296408
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests whether a wearable robotic arm device called MyoPro, combined with motor learning therapy, can improve arm function in people who had a stroke at least six months ago and have severe arm weakness. The device reads muscle signals to help move the arm. Sixty participants will be randomly assigned to receive either therapy with the device or therapy alone. The goal is to see if the device leads to better arm movement and quality of life.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- MyoPro myoelectric orthosis (wearable robotic arm device) plus motor learning-based therapy
- What this could lead to
- If successful, this could provide a new way to help people with long-term severe arm weakness after stroke regain some movement and independence.
- What could go wrong
- This is an early-stage study with only 60 participants, so results may not apply to everyone. The device requires detectable muscle signals, which not all stroke survivors have.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 60 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Apr 2022
- Expected to finish
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Apr 2027
An estimate. End dates often move.
- Lead sponsor
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A government agency
The lead sponsor is a US federal agency other than the NIH.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 89 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * 18-89 years of age * Unilateral arm weakness due to stroke (6 months or more since onset) * Adequate range of motion at the elbow, forearm, wrist, and hand to don the device * Active shoulder flexion of at least 30 degrees and active shoulder abduction of at least 20 degrees * Ability to generate volitional, consistent, and detectable EMG signals from the upper arm and forearm sensor sites with wrist in neutral or flexed positions as detected by the MyoPro software * MAS score less or equal to 3 for the biceps, triceps, supinators and pronators of the impaired arm * Able to read and comprehend the English language * Able to follow directions * Able to provide informed consent * Medically and psychologically stable. * Ability to don/doff MyoPro independently or have support as needed. * Ability to undergo MRI * Ability to undergo TMS procedures Exclusion Criteria: * Previous stroke(s) affecting motor function on the opposite side. * Persistent and severe shoulder subluxation, pain or dislocation * Shoulder passive range of motion \< 45 degrees in flexion and abduction * Fixed upper limb contractures on the impaired arm and hand * Unable to safely support the weight of their arm plus 4 lbs (1.82 kg; the weight of the device) without pain even with arm supported. * Skin rash or open non-healing wound on impaired arm * Involuntary movements of the impaired arm * Pacemaker or other implanted devices that are not compatible with testing procedures or would interfere with donning/doffing and functioning of device. * Metal in the skull or deformity of the skull * Claustrophobia, or inability to operate the MRI patient call button * Contraindications for MRI (standardized screening form for MRI). * Past history of seizures * Family history of medication refractory epilepsy * Pregnancy or pregnancy planning during the study period * Currently taking medications or substances that lower the threshold for onset of seizure.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Louis Stokes VA Medical Center, Cleveland, OH
RECRUITINGCleveland, Ohio, 44106-1702, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- A wearable ankle robot may boost walking recovery after stroke
- Virtual reality rehab aims to bring stroke therapy home
- Which balance training works better after stroke? a trial puts two methods to the test
- Could a cuff and a tingle restore leg strength after stroke?
- Can gentle electrical pulses reawaken hand movement after stroke?
- Can foot sensation predict balance problems in stroke survivors?