Can music soothe cancer anxiety as well as talk therapy?
NCT ID NCT05215353
First seen Jun 26, 2026 · Last updated Aug 19, 2026 · Updated 3 times
Summary
This study compares music therapy and cognitive behavioral therapy (CBT) for reducing anxiety in people who have had cancer. 368 cancer survivors with anxiety will receive seven weekly virtual sessions of either music therapy or CBT. Researchers will track anxiety levels over 26 weeks to see which approach works better and for whom.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Music therapy and cognitive behavioral therapy
- What this could lead to
- If successful, this could show that music therapy is as effective as cognitive behavioral therapy for easing anxiety in cancer survivors, offering a new, accessible option.
- What could go wrong
- This is a Phase 4 study, but it compares two established therapies, not a new drug. Results may show no clear difference, or one therapy may work better for certain individuals. The virtual format may not suit everyone.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Phase 4
Runs after approval, following long-term safety and how well the treatment works in everyday use.
- Participants
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About 368 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Jan 2022
- Expected to finish
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Jan 2027
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * English- or Spanish-speaking * 18 years or older * Prior cancer diagnosis of any type or stage * Free of oncological disease, or stable disease with no evidence of progression * Score of ≥8 on the anxiety subscale of the Hospital Anxiety and Depression Scale (HADS) * Report anxiety symptoms lasting at least one month * Willing to adhere to all study-related procedures, including randomization to one of two treatment arms: MT or CBT * Access to Zoom and a quiet/private location Inclusion Criteria for Advanced Cancer Sub-Study (N=50) * English-speaking * 18 years or older * Advanced cancer diagnosis: stage III or IV lung cancer; any stage pancreatic cancer, unresectable cholangiocarcinoma, unresectable liver cancer, unresectable ampullary or peri-ampullary cancer, or other stage IV gastrointestinal cancer; stage III or IV ovarian or fallopian tube cancers or other stage IV gynecologic cancer; stage IV breast cancer; stage III testicular cancer or any stage IV genitourinary cancer; stage IV sarcoma; stage IV melanoma; stage IV endocrine cancer; lymphoma, myeloma, or leukemia * Currently receiving oncological treatment or on active surveillance * Karnofsky performance score of ≥60 * Score of ≥8 on the HADS anxiety subscale * Anxiety symptoms lasting for at least 1 month * Greater than 6-month expected survival as judged by the treating oncologist * Willing to adhere to all study procedures * Access to Zoom and a quiet/private location Inclusion Criteria for group MT sub-study (N=18) * English-speaking * 18 years or older * Prior cancer diagnosis of any type or stage * Free of oncological disease, or stable disease with no evidence of progression * Score of ≥8 on the anxiety subscale of the Hospital Anxiety and Depression Scale (HADS) * Report anxiety symptoms lasting at least one month * Willing to adhere to all study-related procedures * Access to Zoom and a quiet/private location Exclusion Criteria: * Completed active cancer treatment (e.g., surgery, radiation, chemotherapy) less than one month prior to enrollment (maintenance hormonal or targeted therapies are allowed). * Active suicidal ideation, bipolar disorder, schizophrenia, or substance abuse * Score of ≥10 indicative of cognitive impairment on the Blessed Orientation-Memory-Concentration * Received a treatment course of seven or greater MT or CBT sessions for anxiety symptoms within the last six months * Unable to provide informed consent for themselves Exclusion Criteria for Advanced Cancer Sub-Study * Active suicidal ideation; bipolar disorder, schizophrenia, or substance abuse * Score of ≥10 on Blessed Orientation-Memory-Concentration * Prior receipt of MT within the past six months * Plan to receive any form of psychotherapy in the coming 8 weeks * Initiation or change in anxiety medications within the past 4 weeks * Plan to initiate or change anxiety medications in the coming 8 weeks * Unable to provide informed consent for themselves Exclusion Criteria for group MT sub-study * Completed active cancer treatment (e.g., surgery, radiation, chemotherapy) less than one month prior to enrollment (maintenance hormonal or targeted therapies are allowed). * Active suicidal ideation; bipolar disorder, schizophrenia, or substance abuse * Score of ≥10 on Blessed Orientation-Memory-Concentration * Prior receipt of MT within the past six months * Plan to receive any form of psychotherapy in the coming 8 weeks * Initiation or change in anxiety medications within the past 4 weeks * Unable to provide informed consent for themselves
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
2 sites. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Baptist Alliance MCI
RECRUITINGMiami, Florida, 33143, United States
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Drexel University
ACTIVE_NOT_RECRUITINGPhiladelphia, Pennsylvania, 19104, United States
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Memorial Sloan Kettering Cancer Center
RECRUITINGNew York, New York, 10065, United States
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