New muscle measurement method tested in seniors
NCT ID NCT02062086
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tested a new technique that uses a special form of creatine (deuterated creatine) to measure muscle mass more directly and accurately in older adults. The goal was to see if this method works well in both healthy older adults and those recovering from a hip fracture. The study was stopped early, but it aimed to improve how we track muscle loss in aging.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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33 people
The number who actually took part.
- Started
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Jun 2014
- Finished
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Dec 2018
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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65 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion criteria Population 1: Community-dwelling older adults: * Community-dwelling at the time of the assessment * Ambulatory without human assistance at the time of the assessment * ADL (activity of daily living)equal to 5 or more at the time of the assessment Population 2: Older adults recovering after hip fracture surgery: * Age ≥ 65 at the time of the fracture * Minimal trauma hip fracture (Diagnosis of closed fracture of the proximal femur and no history of a fall from height higher than standing height (e.g. fall from a roof or a ladder); no history of a high impact fracture (e.g. car accident, skiing) * Unilateral hip fracture * Surgical repair of hip fracture * Surgical intervention taking place within 7 days since admission to the acute care unit. * Living in the community at the time of the fracture * Anticipated discharge back to the community * Ambulatory without human assistance prior to the fracture * ADL (activity of daily living) equal to 5 or more prior to the fracture Exclusion criteria Population 1:Community-dwelling elderly: * Diagnosis of dementia * Presence of cognitive impairment (assessed during clinical follow-up using standardized cognitive tools such as MMSE (Mini Mental Status Examination) or MOCA (Montreal Cognitive Assessment), during pre-screening period). * Inability to provide informed consent * Presence of severe or uncontrolled neurodegenerative disease like Parkinson's disease, amyotrophic lateral sclerosis or multiple sclerosis * Presence of an underlying muscle disease other than age-associated muscle waste or disuse atrophy. * History of stroke with residual hemiplegia * Diagnosis of a severe medical or psychiatric condition making the participant unlikely to understand or comply with study protocol. * Diagnosis of malignancy done in the 18 months prior the baseline visit. * Severe renal failure Population 2: Older adults recovering from hip fracture: * Pathological hip fracture * Diagnosis of dementia * Presence of cognitive impairment (assessed during clinical follow-up using standardized cognitive tools such as MMSE (Mini Mental Status Examination) or MOCA (Montreal Cognitive Assessment), during prescreening period). * Peri-operative delirium persisting after day 5 of post-operative period. * Inability to provide informed consent * Presence of severe or uncontrolled neurodegenerative disease like Parkinson's disease, amyotrophic lateral sclerosis or multiple sclerosis * Presence of an underlying muscle disease other than age-associated muscle waste or disuse atrophy. * History of stroke with residual hemiplegia * Diagnosis of a severe medical or psychiatric condition making the participant unlikely to understand or comply with study protocol. * Diagnosis of malignancy done in the 18 months prior the baseline visit. * Severe renal failure
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Gerontopôle - CHU La Grave Casselardit - Serv. de Médecine Interne & de Gérontologie Clinique - 170 av de Casselardit - TSA 40031
Toulouse, 31059, France
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