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Can nerve changes explain Age-Related muscle loss?

NCT ID NCT06496204

Knowledge-focused Sponsor: Karolinska Institutet Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 13, 2026 · Last updated Aug 14, 2026 · Updated 1 time

Summary

This study investigates why muscle strength declines with age, focusing on how changes in muscle innervation and composition may explain individual differences. Researchers are following a group of Swedish men and women who have been part of a physical performance study for nearly 50 years, since age 16. By measuring aerobic capacity, muscle fiber types, and muscular endurance, the project aims to deepen understanding of muscle aging. The findings could help develop strategies to counteract muscle loss and support healthy aging.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this research could uncover why some people lose muscle strength faster with age, potentially guiding strategies to promote healthier aging and lifelong physical activity.
What could go wrong
This is an observational study, so it cannot prove cause and effect. The findings may not apply to everyone, as the participants are a specific group from Sweden.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

429 people

The number who actually took part.

Started

Mar 2021

Finished

Jun 2022

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

se above

Ages

Children (under 18), adults (18 to 64) and older adults (65 and over)

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion criteria: Belonging to the 0.5% of all pupils who entered secondary high school in Sweden in 1974 and attended one of the systematically selected secondary high schools, and was belonging to the systematically selected pupils. Exclusion Criteria: * not being part of the inclusion criteria

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Conditions

The condition(s) this trial relates to.

Sarcopenia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Aerobic fitness Dynapenia Muscle strength Physical fitness Sarcopenia

Contacts and locations

Locations

  • Karolinska institutet

    Stockholm, 14152, Sweden

More trials for these conditions

Other studies related to the condition(s) this trial covers.