New bowel prep pill could make colonoscopies easier
NCT ID NCT07181148
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests a new tablet called MSP01-T for cleaning the bowel before a colonoscopy. About 214 adults will be randomly assigned to take either the new tablet or a standard bowel prep. The goal is to see if the new tablet works just as well and is safe.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- MSP01-T (a bowel cleansing tablet)
- What this could lead to
- If it works, this could offer a simpler or more tolerable way to clean the bowel before a colonoscopy.
- What could go wrong
- This is a phase 3 trial, but it's still testing if the new tablet is as good as existing options. It may not prove superior or could have side effects.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Phase 3
Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.
- Participants
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About 214 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Oct 2025
An estimate. Start dates often move.
- Expected to finish
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May 2026
An estimate. End dates often move.
- Lead sponsor
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A company
The lead sponsor is a pharmaceutical, biotech, or medical-device company.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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19 years and older
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. Male or female participants aged 19 years or older at the time of providing written informed consent. 2. Individuals scheduled to undergo a screening colonoscopy. 3. 19 kg/㎡ ≤ BMI \< 30 kg/㎡ 4. Participants who have voluntarily agreed to participate in the clinical trial and have provided written informed consent. Exclusion Criteria: Participants who meet any of the following will NOT be eligible to participate in this clinical trial: 1. Colonoscopy for therapeutic purposes, including: * Hemostatic treatment after vascular malformation, ulcer, tumor, or polypectomy * Decompression for non-toxic megacolon or sigmoid volvulus * Foreign body removal * Balloon dilation of strictures * Palliative treatment for bleeding due to strictures or tumors 2. Medical history at screening, including: * Epilepsy or seizure within 2 years * Severe cardiac disease within 24 weeks (e.g., unstable angina, acute myocardial infarction) * Clinically significant gastrointestinal or abdominal surgery within 24 weeks (except appendectomy, hemorrhoidectomy) * Active infection or fever ≥ 38°C within 1 week (except mild upper respiratory infection or localized skin infection) * Hypersensitivity to investigational product components 3. Concomitant diseases at screening, including: * Active gastrointestinal bleeding * Coagulation disorders * Gastrointestinal obstruction, perforation, or gastric emptying disorders * Inflammatory bowel disease (e.g., Crohn's disease, toxic megacolon, toxic colitis) * Acute abdomen requiring surgery * Major cardiovascular disease (e.g., congestive heart failure \[NYHA class III-IV\], clinically significant arrhythmia, QTcF \> 450 msec \[male\] or \> 470 msec \[female\]) * Uncontrolled hypertension (systolic blood pressure \> 170 mmHg or diastolic blood pressure \> 100 mmHg) * Insulin therapy requirement * Clinically significant electrolyte imbalance * Risk of dehydration (e.g., rhabdomyolysis, ascites) * Severe renal impairment (eGFR \< 30 mL/min/1.73 m²) * ALT or AST \> 3 × ULN * Severe nausea or vomiting interfering with trial participation * Active hepatitis B (HBsAg positive) or hepatitis C (HCV Ab positive) * HIV positive * Neurological or psychiatric disorders (e.g., depression, bipolar disorder, epilepsy, substance abuse) or use of related medications 4. Medication use: * Severe constipation (bowel movement \< 3/week) or regular use of laxatives/prokinetics within 12 weeks * Use of laxatives, enemas, simethicone, 5-HT4 agonists, iron, or opioids within 7 days before Day 1 5. Pregnant or breastfeeding women 6. Women of childbearing potential and men unwilling to use effective contraception during the study 7. Participation in another clinical trial and receipt of investigational drug or device within 4 weeks 8. Any condition judged inappropriate by the investigator
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
The full official record for this study. This one lists no contact details, but it is the first place any would appear.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Kangbuk Samsung Hospital
Seoul, South Korea
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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- Can one number judge colonoscopy quality for every patient?
- Could a belly belt make colonoscopy easier on everyone?
- Flushing the right colon Mid-Procedure: a new way to catch hidden polyps?
- Can an AI coach on your phone get your gut ready for colonoscopy?
- New bowel preps face off against standard solution in phase 3 trial