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Whole-Body MRI may outshine standard scans for prostate cancer staging
NCT ID NCT03085043
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests whether a special whole-body MRI (diffusion-weighted imaging) can better detect prostate cancer that has spread to bones or lymph nodes compared to standard bone scans and CT scans. About 98 men with high-risk prostate cancer will undergo all three imaging methods, and researchers will compare their accuracy. The goal is to see if this MRI technique can serve as a one-stop staging tool, potentially simplifying diagnosis and improving treatment planning.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Magnetic Resonance Imaging (MRI)
- What this could lead to
- If successful, this could make whole-body MRI a standard, more accurate way to stage high-risk prostate cancer, reducing the need for multiple scans.
- What could go wrong
- This is a small, early-stage study (98 participants) focused on accuracy, not treatment outcomes. The MRI method may not prove better enough to replace current scans in routine practice.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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98 people
The number who actually took part.
- Started
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Apr 2016
- Expected to finish
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Apr 2026
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Male participants only
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Prostate carcinoma patients at high risk for metastasis with prostate-specific antigen (PSA) more than 20 ng/ml and/or Gleason score = 8/ \> 8. * Ability to understand and sign informed consent. Exclusion Criteria: * Patient is at low risk for metastasis with Gleason score at diagnosis \< 8. * Currently receiving or history of systemic therapy with testosterone suppressing medication (i.e., lupron, degarelix, abiraterone, enzalutamide) or local radiation therapy. * Contraindication to magnetic resonance imaging (MRI).
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
M D Anderson Cancer Center
Houston, Texas, 77030, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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