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New drug MRG004A targets tough cancers in early trial

NCT ID NCT04843709

First seen May 14, 2026 · Last updated May 24, 2026 · Updated 2 times

Summary

This early-phase study tested an experimental drug, MRG004A, in 39 adults with advanced or metastatic solid tumors that have a protein called tissue factor. The main goals were to find a safe dose and see if the drug can shrink tumors. Researchers also monitored side effects and how long any tumor response lasted.

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Contacts and locations

Locations

  • Chao Family Comprehensive Cancer Center

    Orange, California, 92868-3201, United States

  • Fudan University Shanghai Cancer Center

    Shanghai, Shanghai Municipality, 201321, China

  • Gabrail Cancer Center Research

    Canton, Ohio, 44718, United States

  • Gettysburg Cancer Center

    Gettysburg, Pennsylvania, 17325, United States

  • Hunan Cancer Hospital

    Changsha, Hunan, 410013, China

  • Memorial Sloan Kettering 60th Street Outpatient Center

    New York, New York, 10065, United States

  • The Christ Hospital Cancer Center

    Cincinnati, Ohio, 45219, United States

  • The First Affiliated Hospital, College of Medicine, Zhejiang University

    Hangzhou, Zhejiang, 310003, China

  • Virginia Cancer Specialists

    Fairfax, Virginia, 22031, United States

Conditions

Explore the condition pages connected to this study.